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Serotonergic development of active sensing

Alireza Azarfar, Yiping Zhang, Artoghrul Alishbayli, Dirk Schubert, Judith R. Homberg, View ORCID ProfileTansu Celikel
doi: https://doi.org/10.1101/762534
Alireza Azarfar
1Department of Neurophysiology, Donders Institute for Brain, Cognition, and Behaviour Radboud University - 6525 HJ Nijmegen, the Netherlands
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Yiping Zhang
1Department of Neurophysiology, Donders Institute for Brain, Cognition, and Behaviour Radboud University - 6525 HJ Nijmegen, the Netherlands
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Artoghrul Alishbayli
1Department of Neurophysiology, Donders Institute for Brain, Cognition, and Behaviour Radboud University - 6525 HJ Nijmegen, the Netherlands
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Dirk Schubert
2Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, - 6525 HJ Nijmegen, the Netherlands
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Judith R. Homberg
2Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, - 6525 HJ Nijmegen, the Netherlands
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Tansu Celikel
1Department of Neurophysiology, Donders Institute for Brain, Cognition, and Behaviour Radboud University - 6525 HJ Nijmegen, the Netherlands
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  • ORCID record for Tansu Celikel
  • For correspondence: celikel@neurophysiology.nl
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Abstract

Active sensing requires adaptive motor (positional) control of sensory organs based on contextual, sensory and task requirements, and develops postnatally after the maturation of intracortical circuits. Alterations in sensorimotor network connectivity during this period are likely to impact sensorimotor computation also in adulthood. Serotonin is among the cardinal developmental regulators of network formation, thus changing the serotonergic drive might have consequences for the emergence and maturation of sensorimotor control. Here we tested this hypothesis on an object localization task by quantifying the motor control dynamics of whiskers during tactile navigation. The results showed that sustained alterations in serotonergic signaling in serotonin transporter knockout rats, or the transient pharmacological inactivation of the transporter during early postnatal development, impairs the emergence of adaptive motor control of whisker position based on recent sensory information. A direct outcome of this altered motor control is that the mechanical force transmitted to whisker follicles upon contact is reduced, suggesting that increased excitability observed upon altered serotonergic signaling is not due to increased synaptic drive originating from the periphery upon whisker contact. These results argue that postnatal development of adaptive motor control requires intact serotonergic signaling and that even its transient dysregulation during early postnatal development causes lasting sensorimotor impairments in adulthood.

Footnotes

  • https://academic.oup.com/gigascience/article/7/12/giy134/5168870

  • https://github.com/DepartmentofNeurophysiology/Circuits-of-whisking

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Serotonergic development of active sensing
Alireza Azarfar, Yiping Zhang, Artoghrul Alishbayli, Dirk Schubert, Judith R. Homberg, Tansu Celikel
bioRxiv 762534; doi: https://doi.org/10.1101/762534
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Serotonergic development of active sensing
Alireza Azarfar, Yiping Zhang, Artoghrul Alishbayli, Dirk Schubert, Judith R. Homberg, Tansu Celikel
bioRxiv 762534; doi: https://doi.org/10.1101/762534

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