Abstract
The network approach to psychopathology has recently received considerable attention, and is as a novel way of conceptualizing mental disorders as causally interacting symptoms. In this study, we modeled a joint network of depression symptoms and depression-related brain structures, using 21 symptoms and five regional brain measures. We used a mixed sample of 268 individuals previously treated for one or more major depressive episodes and never depressed individuals. The network revealed associations between brain structure and unique depressive symptoms, which may clarify relationships regarding symptomatic and biological heterogeneity in depression.
Footnotes
Updated after new analysis, after review in Psychiatry and Clinical Neurosciences.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.