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Topoisomerase II inhibitors induce cGAS-STING dependent inflammation resulting in cytokine induction and immune checkpoint activation
R. D. A Wilkinson, N. McCabe, E. E. Parkes, E.M. Barros, D. I. Johnston, R.M.M Ali, K. Lappin, R.A. Greenberg, D. P. Harkin, View ORCID ProfileS. A. McIntosh, R. D. Kennedy, K. I. Savage
doi: https://doi.org/10.1101/764662
R. D. A Wilkinson
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
N. McCabe
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
2Almac Diagnostic Services, Craigavon, Northern Ireland, United Kingdom, BT9 7AE
E. E. Parkes
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
E.M. Barros
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
D. I. Johnston
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
R.M.M Ali
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
K. Lappin
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
R.A. Greenberg
3Department of Cancer Biology, Basser Center for BRCA, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
D. P. Harkin
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
2Almac Diagnostic Services, Craigavon, Northern Ireland, United Kingdom, BT9 7AE
S. A. McIntosh
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
R. D. Kennedy
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
2Almac Diagnostic Services, Craigavon, Northern Ireland, United Kingdom, BT9 7AE
K. I. Savage
1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom, BT9 7AE
Posted September 10, 2019.
Topoisomerase II inhibitors induce cGAS-STING dependent inflammation resulting in cytokine induction and immune checkpoint activation
R. D. A Wilkinson, N. McCabe, E. E. Parkes, E.M. Barros, D. I. Johnston, R.M.M Ali, K. Lappin, R.A. Greenberg, D. P. Harkin, S. A. McIntosh, R. D. Kennedy, K. I. Savage
bioRxiv 764662; doi: https://doi.org/10.1101/764662
Topoisomerase II inhibitors induce cGAS-STING dependent inflammation resulting in cytokine induction and immune checkpoint activation
R. D. A Wilkinson, N. McCabe, E. E. Parkes, E.M. Barros, D. I. Johnston, R.M.M Ali, K. Lappin, R.A. Greenberg, D. P. Harkin, S. A. McIntosh, R. D. Kennedy, K. I. Savage
bioRxiv 764662; doi: https://doi.org/10.1101/764662
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