Article Information
- September 16, 2019.
Author Information
- Yun Yang1,2,3,
- Victor Tapias2,
- Diana Acosta4,
- Hui Xu2,3,
- Huanlian Chen2,3,
- Ruchika Bhawal5,
- Elizabeth Anderson5,
- Elena Ivanova6,
- Hening Lin7,8,
- Botir T. Sagdullaev9,10,
- William L. Klein11,
- Kirsten L. Viola11,
- Sam Gandy12,
- Vahram Haroutunian13,14,
- M. Flint Beal2,
- David Eliezer4,
- Sheng Zhang5 and
- Gary E. Gibson2,3,*
- 1Integrated Medicine Research Center for Neurological Rehabilitation, College of Medicine, Jiaxing University, Jiaxing, 314001, China
- 2Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA, vit2013{at}med.cornell.edu, fbeal{at}med.cornell.edu
- 3Burke Neurological Institute, White Plains, NY 10605, USA zjxuyang{at}mail.zjxu.edu.cn; yay2007{at}med.cornell.edu; xuh2003{at}med.cornell.edu; huc2006{at}med.cornell.edu; ggibson{at}med.cornell.edu
- 4Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA dia2018{at}med.cornell.edu; dae2005{at}med.cornell.edu
- 5Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY 14853, USA, rb822{at}cornell.edu; eta23{at}cornell.edu, sz14{at}cornell.edu
- 6Imaging Core, Burke Neurological Institute, White Plains, NY 10605, USA eli3001{at}med.cornell.edu
- 7Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
- 8Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. hl379{at}cornell.edu
- 9Ophthalmology and Neuroscience, Weill Cornell Medicine, New York, NY 10065, USA
- 10Laboratory for Visual Plasticity and Repair, Burke Neurological Institute, White Plains, NY 10605, USA, bos2005{at}med.cornell.edu
- 11Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA wklein{at}northwestern.edu; k-viola{at}northwestern.edu
- 12Departments of Neurology and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, samuel.gandy{at}mssm.edu
- 13The Alzheimer’s Disease Research Center, NIH Neurobiobank and JJ Peters VA Medical Center MIRECC
- 14Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA vahram.haroutunian{at}mssm.edu
- ↵*Corresponding author; email: ggibson{at}med.cornell.edu
Author Contributions Y.Y. and G.G. conceived the research program and designed the experiments. V.H. contributed to the patient consent, collection of samples. V.H., X.H. and E.A. processed the brain samples. R.B. and S.Z. performed nanoLC-MS/MS analysis. Y.Y. performed data analyses. Y.Y. and X.H. performed biochemical experiments. Y.Y., X.H., and H.C. performed the cell experiments. X.H., H.C., E.I. and B.T.S. performed immunofluorescence on the rotenone treated cells and analyzed the data. D.A. and D.E. designed and performed NMR analysis, processed and interpreted the data and prepared figures. V.T. and M.F.B. participated in the design and conceptualization of the animal study, performed the experiments, analyzed the data, and prepared the figures. H.L. participated in the experimental design and write-up. S.G., W.K. and K.V. provided antibodies and contributed to the design. Y.Y. and G.G. wrote and edited the manuscript. All authors discussed the results, and Y.Y., G.G., S.Z., D.E., S.G., V.H., V.T., B.T.S, H.L. and E.I. contributed to the writing. All authors read and approved the manuscript.