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Inosine is an alternative carbon supply that supports effector T cell proliferation and antitumor function under glucose restriction
Tingting Wang, JN Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan, Ruoning Wang
doi: https://doi.org/10.1101/766642
Tingting Wang
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
JN Rashida Gnanaprakasam
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
Xuyong Chen
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
Siwen Kang
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
Xuequn Xu
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
Hua Sun
3The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030 USA
Lingling Liu
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
Ethan Miller
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
Teresa A. Cassel
2Center for Environmental and Systems Biochemistry, Dept. of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Qiushi Sun
2Center for Environmental and Systems Biochemistry, Dept. of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Sara Vicente-Muñoz
2Center for Environmental and Systems Biochemistry, Dept. of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Marc O. Warmoes
2Center for Environmental and Systems Biochemistry, Dept. of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Andrew N. Lane
2Center for Environmental and Systems Biochemistry, Dept. of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Xiaotong Song
3The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030 USA
4Icell Kealex Therapeutics, Houston, TX 77021
Teresa W.-M. Fan
2Center for Environmental and Systems Biochemistry, Dept. of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Ruoning Wang
1Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, USA
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Posted September 14, 2019.
Inosine is an alternative carbon supply that supports effector T cell proliferation and antitumor function under glucose restriction
Tingting Wang, JN Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan, Ruoning Wang
bioRxiv 766642; doi: https://doi.org/10.1101/766642
Inosine is an alternative carbon supply that supports effector T cell proliferation and antitumor function under glucose restriction
Tingting Wang, JN Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan, Ruoning Wang
bioRxiv 766642; doi: https://doi.org/10.1101/766642
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