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COMET: A toolkit for composing customizable genetic programs in mammalian cells

Patrick S. Donahue, Joseph W. Draut, Joseph J. Muldoon, Hailey I. Edelstein, Neda Bagheri, View ORCID ProfileJoshua N. Leonard
doi: https://doi.org/10.1101/769794
Patrick S. Donahue
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
2Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois 60208, United States
3Medical Scientist Training Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States
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Joseph W. Draut
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
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Joseph J. Muldoon
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
2Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois 60208, United States
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Hailey I. Edelstein
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
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Neda Bagheri
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
2Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois 60208, United States
4Center for Synthetic Biology, Northwestern University, Evanston, Illinois 60208, United States
5Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States
6Member, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois 60208, United States
7Biology and Chemical Engineering, University of Washington, Seattle, Washington 98195, United States
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Joshua N. Leonard
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
2Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois 60208, United States
4Center for Synthetic Biology, Northwestern University, Evanston, Illinois 60208, United States
5Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States
6Member, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois 60208, United States
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  • ORCID record for Joshua N. Leonard
  • For correspondence: j-leonard@northwestern.edu
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Article Information

doi 
https://doi.org/10.1101/769794
History 
  • September 16, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Patrick S. Donahue1,2,3,
  2. Joseph W. Draut1,8,
  3. Joseph J. Muldoon1,2,8,
  4. Hailey I. Edelstein1,8,
  5. Neda Bagheri1,2,4,5,6,7 and
  6. Joshua N. Leonard1,2,4,5,6,*
  1. 1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States
  2. 2Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois 60208, United States
  3. 3Medical Scientist Training Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States
  4. 4Center for Synthetic Biology, Northwestern University, Evanston, Illinois 60208, United States
  5. 5Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States
  6. 6Member, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois 60208, United States
  7. 7Biology and Chemical Engineering, University of Washington, Seattle, Washington 98195, United States
  1. ↵*Corresponding author: Joshua N. Leonard, j-leonard{at}northwestern.edu
  1. ↵8 These authors contributed equally to this work

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Posted September 16, 2019.
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COMET: A toolkit for composing customizable genetic programs in mammalian cells
Patrick S. Donahue, Joseph W. Draut, Joseph J. Muldoon, Hailey I. Edelstein, Neda Bagheri, Joshua N. Leonard
bioRxiv 769794; doi: https://doi.org/10.1101/769794
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COMET: A toolkit for composing customizable genetic programs in mammalian cells
Patrick S. Donahue, Joseph W. Draut, Joseph J. Muldoon, Hailey I. Edelstein, Neda Bagheri, Joshua N. Leonard
bioRxiv 769794; doi: https://doi.org/10.1101/769794

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