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Nuclear gene proximity and protein interactions shape transcript covariances in mammalian single cells

Marcel Tarbier, Sebastian D. Mackowiak, João Frade, Silvina Catuara-Solarz, Inna Biryukova, Eleni Gelali, Diego Bárcena Menéndez, Luis Zapata, Stephan Ossowski, Magda Bienko, Caroline J. Gallant, Marc R. Friedländer
doi: https://doi.org/10.1101/771402
Marcel Tarbier
1Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
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Sebastian D. Mackowiak
1Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
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João Frade
2Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
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Silvina Catuara-Solarz
2Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
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Inna Biryukova
1Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
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Eleni Gelali
4Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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Diego Bárcena Menéndez
2Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
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Luis Zapata
2Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
5Center for Evolution and Cancer, The Institute of Cancer Research, London, UK
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Stephan Ossowski
2Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
3Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain
6Institute of Medical genetics and Applied Genomics, University of Tübingen, Tübingen, Germany
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Magda Bienko
4Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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Caroline J. Gallant
7Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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Marc R. Friedländer
1Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
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  • For correspondence: marc.friedlander@scilifelab.se
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Article Information

doi 
https://doi.org/10.1101/771402
History 
  • September 16, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Marcel Tarbier1,
  2. Sebastian D. Mackowiak1,*,
  3. João Frade2,*,
  4. Silvina Catuara-Solarz2,
  5. Inna Biryukova1,
  6. Eleni Gelali4,
  7. Diego Bárcena Menéndez2,
  8. Luis Zapata2,5,
  9. Stephan Ossowski2,3,6,
  10. Magda Bienko4,
  11. Caroline J. Gallant7 and
  12. Marc R. Friedländer1,†
  1. 1Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
  2. 2Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
  3. 3Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain
  4. 4Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
  5. 5Center for Evolution and Cancer, The Institute of Cancer Research, London, UK
  6. 6Institute of Medical genetics and Applied Genomics, University of Tübingen, Tübingen, Germany
  7. 7Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  1. ↵†To whom correspondence may be addressed: marc.friedlander{at}scilifelab.se
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Posted September 16, 2019.
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Nuclear gene proximity and protein interactions shape transcript covariances in mammalian single cells
Marcel Tarbier, Sebastian D. Mackowiak, João Frade, Silvina Catuara-Solarz, Inna Biryukova, Eleni Gelali, Diego Bárcena Menéndez, Luis Zapata, Stephan Ossowski, Magda Bienko, Caroline J. Gallant, Marc R. Friedländer
bioRxiv 771402; doi: https://doi.org/10.1101/771402
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Nuclear gene proximity and protein interactions shape transcript covariances in mammalian single cells
Marcel Tarbier, Sebastian D. Mackowiak, João Frade, Silvina Catuara-Solarz, Inna Biryukova, Eleni Gelali, Diego Bárcena Menéndez, Luis Zapata, Stephan Ossowski, Magda Bienko, Caroline J. Gallant, Marc R. Friedländer
bioRxiv 771402; doi: https://doi.org/10.1101/771402

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