Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

View ORCID ProfileRyan von Kleeck, View ORCID ProfileSonja A. Brankovic, Ian Roberts, View ORCID ProfileElizabeth A. Hawthorne, View ORCID ProfileKyle Bruun, Paola Castagnino, View ORCID ProfileRichard K. Assoian
doi: https://doi.org/10.1101/773184
Ryan von Kleeck
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ryan von Kleeck
Sonja A. Brankovic
G.W. Woodruff School of Mechanical Engineering, Georgia Tech, Atlanta GA 30313Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sonja A. Brankovic
Ian Roberts
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth A. Hawthorne
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elizabeth A. Hawthorne
Kyle Bruun
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kyle Bruun
Paola Castagnino
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard K. Assoian
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Richard K. Assoian
  • For correspondence: assoian@pennmedicine.upenn.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Article Information

doi 
https://doi.org/10.1101/773184
History 
  • October 4, 2019.

Article Versions

  • older version (September 18, 2019 - 04:39).
  • You are viewing the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Ryan von Kleeck1,3,
  2. Sonja A. Brankovic*,1,3,
  3. Ian Roberts1,2,
  4. Elizabeth A. Hawthorne1,
  5. Kyle Bruun1,
  6. Paola Castagnino1,2 and
  7. Richard K. Assoian1,2,3,#
  1. 1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104
  2. 2Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104
  3. 3Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
  4. *G.W. Woodruff School of Mechanical Engineering, Georgia Tech, Atlanta GA 30313
  1. ↵#Address editorial correspondence to: Richard K. Assoian, email: assoian{at}pennmedicine.upenn.edu, Tel: 215-898-7157
Back to top
PreviousNext
Posted October 04, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition
Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian
bioRxiv 773184; doi: https://doi.org/10.1101/773184
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition
Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian
bioRxiv 773184; doi: https://doi.org/10.1101/773184

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Molecular Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (1519)
  • Biochemistry (2473)
  • Bioengineering (1727)
  • Bioinformatics (9648)
  • Biophysics (3884)
  • Cancer Biology (2961)
  • Cell Biology (4173)
  • Clinical Trials (135)
  • Developmental Biology (2620)
  • Ecology (4084)
  • Epidemiology (2031)
  • Evolutionary Biology (6868)
  • Genetics (5195)
  • Genomics (6482)
  • Immunology (2176)
  • Microbiology (6909)
  • Molecular Biology (2746)
  • Neuroscience (17197)
  • Paleontology (125)
  • Pathology (425)
  • Pharmacology and Toxicology (703)
  • Physiology (1050)
  • Plant Biology (2478)
  • Scientific Communication and Education (642)
  • Synthetic Biology (828)
  • Systems Biology (2680)
  • Zoology (429)