Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Ryan von Kleeck; Sonja A. Brankovic; Ian Roberts; Elizabeth A. Hawthorne; Kyle Bruun; Paola Castagnino; Richard K. Assoian

doi:10.1101/773184

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Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

View ORCID ProfileRyan von Kleeck, View ORCID ProfileSonja A. Brankovic, Ian Roberts, View ORCID ProfileElizabeth A. Hawthorne, View ORCID ProfileKyle Bruun, Paola Castagnino, View ORCID ProfileRichard K. Assoian

doi: https://doi.org/10.1101/773184

Ryan von Kleeck

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

3Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104

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Sonja A. Brankovic

*G.W. Woodruff School of Mechanical Engineering, Georgia Tech, Atlanta GA 30313

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

3Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104

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Ian Roberts

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

2Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104

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Elizabeth A. Hawthorne

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

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Kyle Bruun

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

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Paola Castagnino

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

2Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104

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Richard K. Assoian

1Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

2Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104

3Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104

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For correspondence: assoian@pennmedicine.upenn.edu

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Posted October 04, 2019.

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Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian

bioRxiv 773184; doi: https://doi.org/10.1101/773184

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Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian

bioRxiv 773184; doi: https://doi.org/10.1101/773184

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