Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Ryan von Kleeck; Sonja A. Brankovic; Ian Roberts; Elizabeth A. Hawthorne; Kyle Bruun; Paola Castagnino; Richard K. Assoian

doi:10.1101/773184

New Results

Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

View ORCID ProfileRyan von Kleeck, View ORCID ProfileSonja A. Brankovic, Ian Roberts, View ORCID ProfileElizabeth A. Hawthorne, View ORCID ProfileKyle Bruun, Paola Castagnino, View ORCID ProfileRichard K. Assoian

doi: https://doi.org/10.1101/773184

Ryan von Kleeck

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ryan von Kleeck

Sonja A. Brankovic

G.W. Woodruff School of Mechanical Engineering, Georgia Tech, Atlanta GA 30313Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sonja A. Brankovic

Ian Roberts

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elizabeth A. Hawthorne

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Elizabeth A. Hawthorne

Kyle Bruun

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kyle Bruun

Paola Castagnino

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Richard K. Assoian

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Richard K. Assoian
For correspondence: assoian@pennmedicine.upenn.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: September 2019 to December 2019

	Abstract	Full	Pdf
Sep 2019	207	5	52
Oct 2019	230	21	44
Nov 2019	31	8	18
Dec 2019	6	2	4

View the discussion thread.

PreviousNext

Posted October 04, 2019.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian

bioRxiv 773184; doi: https://doi.org/10.1101/773184

Share This Article:

Citation Tools

Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian

bioRxiv 773184; doi: https://doi.org/10.1101/773184

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Molecular Biology

Subject Areas

All Articles

Animal Behavior and Cognition (1522)
Biochemistry (2475)
Bioengineering (1731)
Bioinformatics (9655)
Biophysics (3892)
Cancer Biology (2964)
Cell Biology (4185)
Clinical Trials (135)
Developmental Biology (2622)
Ecology (4092)
Epidemiology (2031)
Evolutionary Biology (6884)
Genetics (5202)
Genomics (6490)
Immunology (2181)
Microbiology (6928)
Molecular Biology (2750)
Neuroscience (17245)
Paleontology (126)
Pathology (425)
Pharmacology and Toxicology (705)
Physiology (1055)
Plant Biology (2484)
Scientific Communication and Education (642)
Synthetic Biology (828)
Systems Biology (2684)
Zoology (429)