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Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition

View ORCID ProfileRyan von Kleeck, View ORCID ProfileSonja A. Brankovic, Ian Roberts, View ORCID ProfileElizabeth A. Hawthorne, View ORCID ProfileKyle Bruun, Paola Castagnino, View ORCID ProfileRichard K. Assoian
doi: https://doi.org/10.1101/773184
Ryan von Kleeck
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
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  • ORCID record for Ryan von Kleeck
Sonja A. Brankovic
G.W. Woodruff School of Mechanical Engineering, Georgia Tech, Atlanta GA 30313Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
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  • ORCID record for Sonja A. Brankovic
Ian Roberts
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104
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Elizabeth A. Hawthorne
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104
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  • ORCID record for Elizabeth A. Hawthorne
Kyle Bruun
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104
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  • ORCID record for Kyle Bruun
Paola Castagnino
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104
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Richard K. Assoian
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia PA 19104Center for Engineering MechanoBiology, University of Pennsylvania, Philadelphia PA 19104
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  • ORCID record for Richard K. Assoian
  • For correspondence: assoian@pennmedicine.upenn.edu
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Posted October 04, 2019.
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Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition
Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian
bioRxiv 773184; doi: https://doi.org/10.1101/773184
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Premature arterial stiffening in Hutchinson-Gilford Progeria Syndrome linked to early induction of Lysyl Oxidase (LOX) and corrected by LOX inhibition
Ryan von Kleeck, Sonja A. Brankovic, Ian Roberts, Elizabeth A. Hawthorne, Kyle Bruun, Paola Castagnino, Richard K. Assoian
bioRxiv 773184; doi: https://doi.org/10.1101/773184

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