Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Exercise conditioned plasma dampens inflammation via clusterin and boosts memory

Zurine De Miguel, Michael J. Betley, Drew Willoughby, Benoit Lehallier, Niclas Olsson, Liana Bonanno, Kaci J. Fairchild, Kévin Contrepois, Joshua E. Elias, Thomas A. Rando, View ORCID ProfileTony Wyss-Coray
doi: https://doi.org/10.1101/775288
Zurine De Miguel
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
7Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: twc@stanford.edu zurine@stanford.edu
Michael J. Betley
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
2Neurosciences Graduate Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Drew Willoughby
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benoit Lehallier
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
7Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Niclas Olsson
4Department of Chemical and Systems Biology, Stanford Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Liana Bonanno
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kaci J. Fairchild
5The Veterans Affairs Palo Alto HealthCare System, Palo Alto, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kévin Contrepois
6Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joshua E. Elias
4Department of Chemical and Systems Biology, Stanford Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas A. Rando
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
5The Veterans Affairs Palo Alto HealthCare System, Palo Alto, CA 94305, USA
7Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tony Wyss-Coray
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
5The Veterans Affairs Palo Alto HealthCare System, Palo Alto, CA 94305, USA
7Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
8Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tony Wyss-Coray
  • For correspondence: twc@stanford.edu zurine@stanford.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects. We discovered “runner” plasma, collected from voluntarily running mice, infused into sedentary mice recapitulates the cellular and functional benefits of exercise on the brain. Importantly, runner plasma reduces baseline neuroinflammatory gene expression and prominently suppresses experimentally induced brain inflammation. Plasma proteomic analysis shows a striking increase in complement cascade inhibitors including clusterin, which is necessary for the anti-inflammatory effects of runner plasma. Cognitively impaired patients participating in structured exercise for 6 months showed higher plasma clusterin levels, which correlated positively with improvements in endurance and aerobic capacity. These findings demonstrate the existence of anti-inflammatory “exercise factors” that are transferrable, benefit the brain, and are present in humans engaging in exercise.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted September 19, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Exercise conditioned plasma dampens inflammation via clusterin and boosts memory
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Exercise conditioned plasma dampens inflammation via clusterin and boosts memory
Zurine De Miguel, Michael J. Betley, Drew Willoughby, Benoit Lehallier, Niclas Olsson, Liana Bonanno, Kaci J. Fairchild, Kévin Contrepois, Joshua E. Elias, Thomas A. Rando, Tony Wyss-Coray
bioRxiv 775288; doi: https://doi.org/10.1101/775288
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Exercise conditioned plasma dampens inflammation via clusterin and boosts memory
Zurine De Miguel, Michael J. Betley, Drew Willoughby, Benoit Lehallier, Niclas Olsson, Liana Bonanno, Kaci J. Fairchild, Kévin Contrepois, Joshua E. Elias, Thomas A. Rando, Tony Wyss-Coray
bioRxiv 775288; doi: https://doi.org/10.1101/775288

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3686)
  • Biochemistry (7774)
  • Bioengineering (5668)
  • Bioinformatics (21245)
  • Biophysics (10563)
  • Cancer Biology (8162)
  • Cell Biology (11915)
  • Clinical Trials (138)
  • Developmental Biology (6738)
  • Ecology (10388)
  • Epidemiology (2065)
  • Evolutionary Biology (13843)
  • Genetics (9694)
  • Genomics (13056)
  • Immunology (8123)
  • Microbiology (19956)
  • Molecular Biology (7833)
  • Neuroscience (42973)
  • Paleontology (318)
  • Pathology (1276)
  • Pharmacology and Toxicology (2256)
  • Physiology (3350)
  • Plant Biology (7208)
  • Scientific Communication and Education (1309)
  • Synthetic Biology (1999)
  • Systems Biology (5528)
  • Zoology (1126)