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Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control

W. A. Nazni, A. A. Hoffmann, A. Noor Afizah, Y. L. Cheong, M. V. Mancini, N. Golding, M. R. G. Kamarul, A. K. M. Arif, H. Thohir, H. S. Nur Syamimi, M. Z. Nur Zatil Aqmar, M. M. Nur Ruqqayah, A. Siti Nor Syazwani, A. Faiz, M. N. F. R. Irfan, S. Rubaaini, N. Nuradila, M. M. N. Nizam, M. S. Mohamad Irwan, N. M. Endersby-Harshman, V. L. White, T. H. Ant, C. Herd, H. A. Hasnor, R. Abu Bakar, M. D. Hapsah, K. Khadijah, D. Kamilan, S. C. Lee, M. Paid, K. Fadzilah, B. S. Gill, H. L. Lee, View ORCID ProfileS. P. Sinkins
doi: https://doi.org/10.1101/775965
W. A. Nazni
1Institute for Medical Research, Kuala Lumpur, Malaysia
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  • For correspondence: steven.sinkins@glasgow.ac.uk ary@unimelb.edu.au nazni@imr.gov.my
A. A. Hoffmann
2University of Melbourne, Bio21 Institute and the School of BioSciences, Melbourne, Australia
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A. Noor Afizah
1Institute for Medical Research, Kuala Lumpur, Malaysia
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Y. L. Cheong
1Institute for Medical Research, Kuala Lumpur, Malaysia
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M. V. Mancini
3MRC-University of Glasgow Centre for Virus Research, Glasgow, UK
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N. Golding
4University of Melbourne, School of BioSciences, Melbourne, Australia
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M. R. G. Kamarul
1Institute for Medical Research, Kuala Lumpur, Malaysia
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A. K. M. Arif
1Institute for Medical Research, Kuala Lumpur, Malaysia
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H. Thohir
1Institute for Medical Research, Kuala Lumpur, Malaysia
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H. S. Nur Syamimi
1Institute for Medical Research, Kuala Lumpur, Malaysia
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M. Z. Nur Zatil Aqmar
1Institute for Medical Research, Kuala Lumpur, Malaysia
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M. M. Nur Ruqqayah
1Institute for Medical Research, Kuala Lumpur, Malaysia
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A. Siti Nor Syazwani
1Institute for Medical Research, Kuala Lumpur, Malaysia
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A. Faiz
1Institute for Medical Research, Kuala Lumpur, Malaysia
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M. N. F. R. Irfan
1Institute for Medical Research, Kuala Lumpur, Malaysia
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S. Rubaaini
1Institute for Medical Research, Kuala Lumpur, Malaysia
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N. Nuradila
1Institute for Medical Research, Kuala Lumpur, Malaysia
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M. M. N. Nizam
1Institute for Medical Research, Kuala Lumpur, Malaysia
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M. S. Mohamad Irwan
1Institute for Medical Research, Kuala Lumpur, Malaysia
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N. M. Endersby-Harshman
2University of Melbourne, Bio21 Institute and the School of BioSciences, Melbourne, Australia
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V. L. White
2University of Melbourne, Bio21 Institute and the School of BioSciences, Melbourne, Australia
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T. H. Ant
3MRC-University of Glasgow Centre for Virus Research, Glasgow, UK
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C. Herd
3MRC-University of Glasgow Centre for Virus Research, Glasgow, UK
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H. A. Hasnor
5Institute for Health Behavioural Research (IPTK), Kuala Lumpur, Malaysia
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R. Abu Bakar
5Institute for Health Behavioural Research (IPTK), Kuala Lumpur, Malaysia
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M. D. Hapsah
5Institute for Health Behavioural Research (IPTK), Kuala Lumpur, Malaysia
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K. Khadijah
6Petaling District Health Office, Selangor, Malaysia
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D. Kamilan
6Petaling District Health Office, Selangor, Malaysia
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S. C. Lee
6Petaling District Health Office, Selangor, Malaysia
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M. Paid
6Petaling District Health Office, Selangor, Malaysia
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K. Fadzilah
1Institute for Medical Research, Kuala Lumpur, Malaysia
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B. S. Gill
1Institute for Medical Research, Kuala Lumpur, Malaysia
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H. L. Lee
1Institute for Medical Research, Kuala Lumpur, Malaysia
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S. P. Sinkins
3MRC-University of Glasgow Centre for Virus Research, Glasgow, UK
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  • ORCID record for S. P. Sinkins
  • For correspondence: steven.sinkins@glasgow.ac.uk ary@unimelb.edu.au nazni@imr.gov.my
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Abstract

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites, or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

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Posted September 20, 2019.
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Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control
W. A. Nazni, A. A. Hoffmann, A. Noor Afizah, Y. L. Cheong, M. V. Mancini, N. Golding, M. R. G. Kamarul, A. K. M. Arif, H. Thohir, H. S. Nur Syamimi, M. Z. Nur Zatil Aqmar, M. M. Nur Ruqqayah, A. Siti Nor Syazwani, A. Faiz, M. N. F. R. Irfan, S. Rubaaini, N. Nuradila, M. M. N. Nizam, M. S. Mohamad Irwan, N. M. Endersby-Harshman, V. L. White, T. H. Ant, C. Herd, H. A. Hasnor, R. Abu Bakar, M. D. Hapsah, K. Khadijah, D. Kamilan, S. C. Lee, M. Paid, K. Fadzilah, B. S. Gill, H. L. Lee, S. P. Sinkins
bioRxiv 775965; doi: https://doi.org/10.1101/775965
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Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control
W. A. Nazni, A. A. Hoffmann, A. Noor Afizah, Y. L. Cheong, M. V. Mancini, N. Golding, M. R. G. Kamarul, A. K. M. Arif, H. Thohir, H. S. Nur Syamimi, M. Z. Nur Zatil Aqmar, M. M. Nur Ruqqayah, A. Siti Nor Syazwani, A. Faiz, M. N. F. R. Irfan, S. Rubaaini, N. Nuradila, M. M. N. Nizam, M. S. Mohamad Irwan, N. M. Endersby-Harshman, V. L. White, T. H. Ant, C. Herd, H. A. Hasnor, R. Abu Bakar, M. D. Hapsah, K. Khadijah, D. Kamilan, S. C. Lee, M. Paid, K. Fadzilah, B. S. Gill, H. L. Lee, S. P. Sinkins
bioRxiv 775965; doi: https://doi.org/10.1101/775965

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