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OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis
Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Sofie Voet, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Manolis Pasparakis, Mathieu JM Bertrand, Geert van Loo
doi: https://doi.org/10.1101/776088
Lien Verboom
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Arne Martens
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Dario Priem
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Esther Hoste
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Mozes Sze
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Hanna Vikkula
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Sofie Voet
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Laura Bongiovanni
3Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht NL-3584, The Netherlands
4University Medical Center Groningen, Department of Pediatrics, University of Groningen, Groningen NL-9713, The Netherlands
Alain de Bruin
3Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht NL-3584, The Netherlands
4University Medical Center Groningen, Department of Pediatrics, University of Groningen, Groningen NL-9713, The Netherlands
Charlotte L. Scott
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Manolis Pasparakis
5Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50931 Cologne, Germany
Mathieu JM Bertrand
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Geert van Loo
1VIB Center for Inflammation Research, B-9052 Ghent, Belgium
2Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
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Posted September 19, 2019.
OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis
Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Sofie Voet, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Manolis Pasparakis, Mathieu JM Bertrand, Geert van Loo
bioRxiv 776088; doi: https://doi.org/10.1101/776088
OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis
Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Sofie Voet, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Manolis Pasparakis, Mathieu JM Bertrand, Geert van Loo
bioRxiv 776088; doi: https://doi.org/10.1101/776088
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