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Central thalamus modulates consciousness by controlling layer-specific cortical interactions

View ORCID ProfileMichelle J. Redinbaugh, Jessica M. Phillips, View ORCID ProfileNiranjan A. Kambi, View ORCID ProfileSounak Mohanta, Samantha Andryk, Gaven L. Dooley, View ORCID ProfileMohsen Afrasiabi, View ORCID ProfileAeyal Raz, View ORCID ProfileYuri B. Saalmann
doi: https://doi.org/10.1101/776591
Michelle J. Redinbaugh
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USAWisconsin National Primate Research Center, Madison, WI, USA
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  • ORCID record for Michelle J. Redinbaugh
  • For correspondence: mredinbaugh@wisc.edu saalmann@wisc.edu
Jessica M. Phillips
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USAWisconsin National Primate Research Center, Madison, WI, USA
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Niranjan A. Kambi
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USAWisconsin National Primate Research Center, Madison, WI, USA
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  • ORCID record for Niranjan A. Kambi
Sounak Mohanta
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USAWisconsin National Primate Research Center, Madison, WI, USA
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Samantha Andryk
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA
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Gaven L. Dooley
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA
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Mohsen Afrasiabi
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA
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  • ORCID record for Mohsen Afrasiabi
Aeyal Raz
Department of Anesthesiology, University of Wisconsin-Madison, Madison, WI, USADepartment of Anesthesiology, Rambam Health Care Campus, Haifa, Israel
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Yuri B. Saalmann
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USAWisconsin National Primate Research Center, Madison, WI, USA
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  • ORCID record for Yuri B. Saalmann
  • For correspondence: mredinbaugh@wisc.edu saalmann@wisc.edu
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Abstract

Consciousness is the capacity to experience one’s environment and internal states. The minimal mechanisms sufficient to produce this experience, the neural correlates of consciousness (NCC), are thought to involve thalamocortical and intracortical interactions, but the key operations and circuit paths are unclear. We simultaneously recorded neural activity in central thalamus and across layers of fronto-parietal cortex in awake, sleeping and anesthetized macaques. Spiking activity was selectively reduced in deep cortical layers and thalamus during unconsciousness, as were intracolumnar and interareal interactions at alpha and gamma frequencies. Gamma-frequency stimulation, when focused on the central lateral thalamus of anesthetized macaques, counteracted these neural changes and restored consciousness. These findings suggest that the NCC involve both corticocortical feedforward and feedback pathways coordinated with intracolumnar and thalamocortical loops.

Summary Stimulation of central lateral thalamus counters anesthesia to restore wake cortical dynamics and consciousness.

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Posted October 01, 2019.
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Central thalamus modulates consciousness by controlling layer-specific cortical interactions
Michelle J. Redinbaugh, Jessica M. Phillips, Niranjan A. Kambi, Sounak Mohanta, Samantha Andryk, Gaven L. Dooley, Mohsen Afrasiabi, Aeyal Raz, Yuri B. Saalmann
bioRxiv 776591; doi: https://doi.org/10.1101/776591
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Central thalamus modulates consciousness by controlling layer-specific cortical interactions
Michelle J. Redinbaugh, Jessica M. Phillips, Niranjan A. Kambi, Sounak Mohanta, Samantha Andryk, Gaven L. Dooley, Mohsen Afrasiabi, Aeyal Raz, Yuri B. Saalmann
bioRxiv 776591; doi: https://doi.org/10.1101/776591

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