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Secondary Motor Cortex Transforms Spatial Information into Planned Action During Navigation

View ORCID ProfileJacob M. Olson, View ORCID ProfileJamie Li, View ORCID ProfileSarah E. Montgomery, Douglas A. Nitz
doi: https://doi.org/10.1101/776765
Jacob M. Olson
1Brandeis University;
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  • For correspondence: jmolson@brandeis.edu
Jamie Li
2Stanford University;
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Sarah E. Montgomery
3Icahn School of Medicine at Mount Sinai;
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Douglas A. Nitz
4University of California, San Diego
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Abstract

Fluid navigation requires constant updating of planned movements to adapt to evolving obstacles and goals. A neural substrate for navigation demands spatial and environmental information and the ability to effect actions through efferents. Secondary motor cortex is a prime candidate for this role given its interconnectivity with association cortices that encode spatial relationships and its projection to primary motor cortex. Here we report that secondary motor cortex neurons robustly encode both planned and current left/right turning actions across multiple turn locations in a multi-route navigational task. Comparisons within a common statistical framework reveal that secondary motor cortex neurons differentiate contextual factors including environmental position, route, action sequence, orientation, and choice availability. Despite significant modulation by context, action planning and execution are the dominant output signals of secondary motor cortex neurons. These results identify secondary motor cortex as a structure integrating environmental context toward the updating of planned movements.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 11, 2019.
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Secondary Motor Cortex Transforms Spatial Information into Planned Action During Navigation
Jacob M. Olson, Jamie Li, Sarah E. Montgomery, Douglas A. Nitz
bioRxiv 776765; doi: https://doi.org/10.1101/776765
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Secondary Motor Cortex Transforms Spatial Information into Planned Action During Navigation
Jacob M. Olson, Jamie Li, Sarah E. Montgomery, Douglas A. Nitz
bioRxiv 776765; doi: https://doi.org/10.1101/776765

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