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Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva

Eryn Slankster, Sai Kollala, Dominique Baria, Brianna Dailey-Krempel, Roshni Jain, Seth R. Odell, View ORCID ProfileDennis Mathew
doi: https://doi.org/10.1101/781682
Eryn Slankster
1Department of Biology, University of Nevada, Reno, NV, USA
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Sai Kollala
1Department of Biology, University of Nevada, Reno, NV, USA
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Dominique Baria
1Department of Biology, University of Nevada, Reno, NV, USA
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Brianna Dailey-Krempel
1Department of Biology, University of Nevada, Reno, NV, USA
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Roshni Jain
1Department of Biology, University of Nevada, Reno, NV, USA
2Cell and Molecular Biology Graduate Program, University of Nevada, Reno, NV, USA
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Seth R. Odell
1Department of Biology, University of Nevada, Reno, NV, USA
3Integrated Neuroscience Graduate Program, University of Nevada, Reno, NV, USA
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Dennis Mathew
1Department of Biology, University of Nevada, Reno, NV, USA
2Cell and Molecular Biology Graduate Program, University of Nevada, Reno, NV, USA
3Integrated Neuroscience Graduate Program, University of Nevada, Reno, NV, USA
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  • ORCID record for Dennis Mathew
  • For correspondence: dennismathew@unr.edu
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ABSTRACT

Starvation enhances olfactory sensitivity that encourage animals to search for food. The molecular mechanisms that enable sensory neurons to remain flexible and adapt to a particular internal state remain poorly understood. Here, we study the roles of GABA and insulin signaling in starvation-dependent modulation of olfactory sensory neuron (OSN) function in the Drosophila larva. We show that GABAB-receptor and insulin-receptor are necessary for OSN modulation. Using a novel OSN-specific gene expression analysis, we explore downstream targets of insulin signaling in OSNs. Our results strongly suggest that insulin and GABA signaling pathways interact within OSNs and modulate OSN function by impacting olfactory information processing and neurotransmission. We further show that manipulating these signaling pathways specifically in the OSNs impact larval feeding behavior and its body weight. These results challenge the prevailing model of OSN modulation and highlight opportunities to better understand OSN modulation mechanisms and their relationship to animal physiology.

Footnotes

  • Conflict of Interest: The authors declare no competing financial interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 25, 2019.
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Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva
Eryn Slankster, Sai Kollala, Dominique Baria, Brianna Dailey-Krempel, Roshni Jain, Seth R. Odell, Dennis Mathew
bioRxiv 781682; doi: https://doi.org/10.1101/781682
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Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva
Eryn Slankster, Sai Kollala, Dominique Baria, Brianna Dailey-Krempel, Roshni Jain, Seth R. Odell, Dennis Mathew
bioRxiv 781682; doi: https://doi.org/10.1101/781682

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