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Dynamic reconfiguration, fragmentation and integration of whole-brain modular structure across depths of unconsciousness

View ORCID ProfileDominic Standage, Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Dietmar Heinke, Ravi S. Menon, Stefan Everling, View ORCID ProfileJason P. Gallivan
doi: https://doi.org/10.1101/783175
Dominic Standage
1School of Psychology, University of Birmingham, Birmingham, UK
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  • For correspondence: d.standage@bham.ac.uk gallivan@queensu.ca
Corson N. Areshenkoff
2Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada
3Department of Psychology, Queen’s University, Kingston, Ontario, Canada
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Joseph Y. Nashed
2Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada
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R. Matthew Hutchison
5Biogen, Cambridge, Massachusetts, USA
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Melina Hutchison
6Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
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Dietmar Heinke
1School of Psychology, University of Birmingham, Birmingham, UK
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Ravi S. Menon
7Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
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Stefan Everling
7Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
8Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
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Jason P. Gallivan
2Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada
3Department of Psychology, Queen’s University, Kingston, Ontario, Canada
4Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
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  • ORCID record for Jason P. Gallivan
  • For correspondence: d.standage@bham.ac.uk gallivan@queensu.ca
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Abstract

General anesthetics are routinely used to induce unconsciousness, and much is known about their effects on receptor function and single neuron activity. Much less is known about how these local effects are manifest at the whole-brain level, nor how they influence network dynamics, especially past the point of induced unconsciousness. Using resting-state functional magnetic resonance imaging (fMRI) with nonhuman primates, we investigated the dose-dependent effects of anesthesia on whole-brain temporal modular structure, following loss of consciousness. We found that higher isoflurane dose was associated with an increase in both the number and isolation of whole-brain modules, as well as an increase in the uncoordinated movement of brain regions between those modules. Conversely, we found that higher dose was associated with a decrease in the cohesive movement of brain regions between modules, as well as a decrease in the proportion of modules in which brain regions participated. Moreover, higher dose was associated with a decrease in the overall integrity of networks derived from the temporal modules, with the exception of a single, sensory-motor network. Together, these findings suggest that anaesthesia-induced unconsciousness results from the hierarchical fragmentation of dynamic whole-brain network structure, leading to the discoordination of temporal interactions between cortical modules.

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  • The authors declare no competing financial interests.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 27, 2019.
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Dynamic reconfiguration, fragmentation and integration of whole-brain modular structure across depths of unconsciousness
Dominic Standage, Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Dietmar Heinke, Ravi S. Menon, Stefan Everling, Jason P. Gallivan
bioRxiv 783175; doi: https://doi.org/10.1101/783175
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Dynamic reconfiguration, fragmentation and integration of whole-brain modular structure across depths of unconsciousness
Dominic Standage, Corson N. Areshenkoff, Joseph Y. Nashed, R. Matthew Hutchison, Melina Hutchison, Dietmar Heinke, Ravi S. Menon, Stefan Everling, Jason P. Gallivan
bioRxiv 783175; doi: https://doi.org/10.1101/783175

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