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A T cell behavioral manifold couples speed and turning to create heterogeneity in vivo

Elizabeth R. Jerison, Stephen R. Quake
doi: https://doi.org/10.1101/785964
Elizabeth R. Jerison
Department of Applied Physics, Stanford University, Stanford, CA 94305
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Stephen R. Quake
Department of Applied Physics, Stanford University, Stanford, CA 94305Department of Bioengineering, Stanford University, Stanford, CA 94305Chan Zuckerberg Biohub, San Francisco, CA 94158
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  • For correspondence: steve@quake-lab.org
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Abstract

Immune cells carry out dynamic search processes for antigen and pathogens. T cells in vivo migrate primarily via undirected random walks, but it remains unresolved how these random walks generate a characteristic search behavior. Here we use light sheet microscopy to observe the native population of T cells in the larval zebrafish tail and fin fold over long times. We find that cell-to-cell variability is amplified by a correlation between speed and directional persistence, generating a characteristic cell behavioral manifold that is preserved under a perturbation to cell speeds. Our results suggest that speed-persistence coupling may be an intrinsic feature of T cell migration that provides an alternative to Levy flight for accessing a broad range of length scales in vivo.

Footnotes

  • https://www.github.com/erjerison/TCellMigration

  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137770

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 27, 2019.
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A T cell behavioral manifold couples speed and turning to create heterogeneity in vivo
Elizabeth R. Jerison, Stephen R. Quake
bioRxiv 785964; doi: https://doi.org/10.1101/785964
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A T cell behavioral manifold couples speed and turning to create heterogeneity in vivo
Elizabeth R. Jerison, Stephen R. Quake
bioRxiv 785964; doi: https://doi.org/10.1101/785964

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