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Predictive Representations in Hippocampal and Prefrontal Hierarchies

View ORCID ProfileIva K. Brunec, View ORCID ProfileIda Momennejad
doi: https://doi.org/10.1101/786434
Iva K. Brunec
1Department of Psychology, University of Toronto
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Ida Momennejad
2Department of Biomedical Engineering, Columbia University
3Microsoft Research, New York City
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  • For correspondence: im2539@columbia.edu
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Abstract

As we navigate the world, we use learned representations of relational structures to explore and reach goals. Studies of how relational knowledge enables inference and planning are typically conducted in controlled small-scale settings. It remains unclear, however, how people use stored knowledge in continuously unfolding navigation, e.g., walking long distances in a city. We hypothesized that predictive representations, organized at multiple scales along posterior-anterior prefrontal and hippocampal hierarchies, guide naturalistic navigation. We conducted model-based representational similarity analyses of neuroimaging data measured during navigation of realistically long paths in virtual reality. We tested the pattern similarity of each point–along each path–to a weighted sum of its successor points within different predictive horizons. We found that anterior PFC showed the largest predictive horizons, posterior hippocampus the smallest, with the anterior hippocampus and orbitofrontal regions in between. Our findings offer novel insights into how cognitive maps support hierarchical planning at multiple scales.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • We reanalyzed data and included the results, added further explanations of our methods, and overall improved the clarity of our conceptual and data figures.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted July 14, 2020.
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Predictive Representations in Hippocampal and Prefrontal Hierarchies
Iva K. Brunec, Ida Momennejad
bioRxiv 786434; doi: https://doi.org/10.1101/786434
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Predictive Representations in Hippocampal and Prefrontal Hierarchies
Iva K. Brunec, Ida Momennejad
bioRxiv 786434; doi: https://doi.org/10.1101/786434

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