Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

The sensory representation of causally controlled objects

View ORCID ProfileKelly B. Clancy, View ORCID ProfileThomas D. Mrsic-Flogel
doi: https://doi.org/10.1101/786467
Kelly B. Clancy
Sainsbury Wellcome Centre, UCL, 25 Howland Street London, W1T 4JG, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kelly B. Clancy
Thomas D. Mrsic-Flogel
Sainsbury Wellcome Centre, UCL, 25 Howland Street London, W1T 4JG, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Thomas D. Mrsic-Flogel
  • For correspondence: k.clancy@ucl.ac.uk t.mrsic-flogel@ucl.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Intentional control over external objects is informed by our sensory experience of them, in a continuous dialogue between action and perception. How such control is represented at the sensory level, however, is not understood. Here we devised a brain machine interface (BMI) task that enabled mice to guide a visual cursor to a target location for reward, using activity in brain areas recorded with widefield calcium imaging. Parietal and higher visual cortical regions were more engaged when expert animals controlled the cursor, but not in naïve mice learning the task. Intentional control enhanced responses: single-cell recordings from parietal cortex indicated that the same visual cursor elicited larger responses when mice controlled it than when they passively viewed it. Moreover, neural responses were greater when the cursor was moving towards the target than away from it. Thus, the sensory representation of a causally-controlled object is sensitive to a subject’s intention, as well as the object’s instantaneous trajectory relative to the subject’s goal: potentially strengthening the sensory feedback signal to adjudicating areas for exerting more fluent control.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Back to top
PreviousNext
Posted September 30, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
The sensory representation of causally controlled objects
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
The sensory representation of causally controlled objects
Kelly B. Clancy, Thomas D. Mrsic-Flogel
bioRxiv 786467; doi: https://doi.org/10.1101/786467
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
The sensory representation of causally controlled objects
Kelly B. Clancy, Thomas D. Mrsic-Flogel
bioRxiv 786467; doi: https://doi.org/10.1101/786467

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1544)
  • Biochemistry (2500)
  • Bioengineering (1757)
  • Bioinformatics (9727)
  • Biophysics (3928)
  • Cancer Biology (2990)
  • Cell Biology (4235)
  • Clinical Trials (135)
  • Developmental Biology (2653)
  • Ecology (4129)
  • Epidemiology (2033)
  • Evolutionary Biology (6931)
  • Genetics (5243)
  • Genomics (6531)
  • Immunology (2207)
  • Microbiology (7012)
  • Molecular Biology (2782)
  • Neuroscience (17410)
  • Paleontology (127)
  • Pathology (432)
  • Pharmacology and Toxicology (712)
  • Physiology (1068)
  • Plant Biology (2515)
  • Scientific Communication and Education (647)
  • Synthetic Biology (835)
  • Systems Biology (2698)
  • Zoology (439)