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Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit

Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Lingling Chen, Ryan T. Ash, Stelios Smirnakis, Rahul Simha, Linda Kusner, Chen Zeng, Hui Lu
doi: https://doi.org/10.1101/786822
Yuanlei Yue
1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
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Pan Xu
1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
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Zhichao Liu
2Department of Physics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA
3Current address: School of Biological Information, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
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Xiaoqian Sun
4Department of Computer Science, School of Engineering and Applied Science, The George Washington University, Washington, DC 20037, USA
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Juntao Su
5Department of Statistics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA
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Hongfei Du
5Department of Statistics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA
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Lingling Chen
1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
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Ryan T. Ash
6Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA
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Stelios Smirnakis
7Department of Neurology, Brigham and Women’s Hospital, Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA 02115, USA
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Rahul Simha
4Department of Computer Science, School of Engineering and Applied Science, The George Washington University, Washington, DC 20037, USA
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Linda Kusner
1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
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Chen Zeng
2Department of Physics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA
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Hui Lu
1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
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  • For correspondence: huilu@email.gwu.edu
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Article Information

doi 
https://doi.org/10.1101/786822
History 
  • August 11, 2021.

Article Versions

  • Version 1 (September 30, 2019 - 12:56).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Yuanlei Yue1,§,
  2. Pan Xu1,§,
  3. Zhichao Liu2,3,§,
  4. Xiaoqian Sun4,
  5. Juntao Su5,
  6. Hongfei Du5,
  7. Lingling Chen1,
  8. Ryan T. Ash6,
  9. Stelios Smirnakis7,
  10. Rahul Simha4,
  11. Linda Kusner1,
  12. Chen Zeng2 and
  13. Hui Lu1,*
  1. 1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
  2. 2Department of Physics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA
  3. 3Current address: School of Biological Information, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
  4. 4Department of Computer Science, School of Engineering and Applied Science, The George Washington University, Washington, DC 20037, USA
  5. 5Department of Statistics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA
  6. 6Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA
  7. 7Department of Neurology, Brigham and Women’s Hospital, Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA 02115, USA
  1. ↵*Corresponding author: huilu{at}email.gwu.edu
  1. ↵§ These authors contributed equally to this work.

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Posted August 11, 2021.
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Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit
Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Lingling Chen, Ryan T. Ash, Stelios Smirnakis, Rahul Simha, Linda Kusner, Chen Zeng, Hui Lu
bioRxiv 786822; doi: https://doi.org/10.1101/786822
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Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit
Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Lingling Chen, Ryan T. Ash, Stelios Smirnakis, Rahul Simha, Linda Kusner, Chen Zeng, Hui Lu
bioRxiv 786822; doi: https://doi.org/10.1101/786822

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