Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit

Yuanlei Yue; Pan Xu; Zhichao Liu; Xiaoqian Sun; Juntao Su; Hongfei Du; Lingling Chen; Ryan T. Ash; Stelios Smirnakis; Rahul Simha; Linda Kusner; Chen Zeng; Hui Lu

doi:10.1101/786822

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Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit

Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Lingling Chen, Ryan T. Ash, Stelios Smirnakis, Rahul Simha, Linda Kusner, Chen Zeng, Hui Lu

doi: https://doi.org/10.1101/786822

Yuanlei Yue

1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA

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Pan Xu

1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA

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Zhichao Liu

2Department of Physics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA

3Current address: School of Biological Information, Chongqing University of Posts and Telecommunications, Chongqing 400065, China

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Xiaoqian Sun

4Department of Computer Science, School of Engineering and Applied Science, The George Washington University, Washington, DC 20037, USA

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Juntao Su

5Department of Statistics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA

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Hongfei Du

5Department of Statistics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA

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Lingling Chen

1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA

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Ryan T. Ash

6Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA

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Stelios Smirnakis

7Department of Neurology, Brigham and Women’s Hospital, Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA 02115, USA

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Rahul Simha

4Department of Computer Science, School of Engineering and Applied Science, The George Washington University, Washington, DC 20037, USA

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Linda Kusner

1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA

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Chen Zeng

2Department of Physics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA

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Hui Lu

1Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA

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For correspondence: huilu@email.gwu.edu

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Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit

Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Lingling Chen, Ryan T. Ash, Stelios Smirnakis, Rahul Simha, Linda Kusner, Chen Zeng, Hui Lu

bioRxiv 786822; doi: https://doi.org/10.1101/786822

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Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit

Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Lingling Chen, Ryan T. Ash, Stelios Smirnakis, Rahul Simha, Linda Kusner, Chen Zeng, Hui Lu

bioRxiv 786822; doi: https://doi.org/10.1101/786822

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