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Robustness and universality in organelle size control

Kiandokht Panjtan Amiri, Asa Kalish, Shankar Mukherji
doi: https://doi.org/10.1101/789453
Kiandokht Panjtan Amiri
1Department of Physics, Washington University in St. Louis, St. Louis, MO
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Asa Kalish
1Department of Physics, Washington University in St. Louis, St. Louis, MO
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Shankar Mukherji
1Department of Physics, Washington University in St. Louis, St. Louis, MO
2Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO
3Center for the Science and Engineering of Living Systems, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO
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  • For correspondence: smukherji@wustl.edu
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ABSTRACT

One of the grand challenges in quantitative cell biology is understanding the precision with which cells assemble and maintain subcellular organelles. A critical property that governs organelle function is its size. Organelle sizes must be flexible enough to allow cells to grow or shrink them as environments demand, yet be maintained within homeostatic limits. Despite identification of numerous molecular factors that regulate organelle sizes we lack insight into the quantitative principles underlying organelle size control. Here we examine organelle sizes from Saccharomyces cerevisiae and human iPS cells with mathematical theory to show that cells can robustly control average fluctuations in organelle size. By demonstrating that organelle sizes obey a universal scaling relationship we predict theoretically, our framework suggests that organelles grow in random bursts from a limited pool of building blocks. Burst-like growth provides a general biophysical mechanism by which cells can maintain on average reliable yet plastic organelle sizes.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Data-driven rescaling method to test model with no fitting parameters used. Extension of findings to Golgi and mitochondria of mammalian iPS cells.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 18, 2020.
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Robustness and universality in organelle size control
Kiandokht Panjtan Amiri, Asa Kalish, Shankar Mukherji
bioRxiv 789453; doi: https://doi.org/10.1101/789453
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Robustness and universality in organelle size control
Kiandokht Panjtan Amiri, Asa Kalish, Shankar Mukherji
bioRxiv 789453; doi: https://doi.org/10.1101/789453

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