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Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics

Yue Wu, View ORCID ProfileKeith B. Hengen, View ORCID ProfileGina G. Turrigiano, View ORCID ProfileJulijana Gjorgjieva
doi: https://doi.org/10.1101/790410
Yue Wu
1Max Planck Institute for Brain Research, 60438 Frankfurt, Germany
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Keith B. Hengen
2Department of Biology, Brandeis University, Waltham, MA 02454, USA
3Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA
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Gina G. Turrigiano
2Department of Biology, Brandeis University, Waltham, MA 02454, USA
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  • For correspondence: gjorgjieva@brain.mpg.de turrigiano@brandeis.edu
Julijana Gjorgjieva
1Max Planck Institute for Brain Research, 60438 Frankfurt, Germany
4Technical University of Munich, School of Life Sciences, 85354 Freising, Germany
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  • For correspondence: gjorgjieva@brain.mpg.de turrigiano@brandeis.edu
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Abstract

Homeostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity. Although it is commonly assumed that homeostasis modulates synaptic strength, membrane excitability and firing rates, its role at the neural circuit and network level is unknown. Here, we identify changes in higher-order network properties of freely behaving rodents during prolonged visual deprivation. Strikingly, our data reveal that pairwise functional correlations and their structure are subject to homeostatic regulation. Using a computational model, we demonstrate that the interplay of different plasticity and homeostatic mechanisms can capture the initial drop and delayed recovery of firing rates and correlations observed experimentally. Moreover, our model indicates that synaptic scaling is crucial for the recovery of correlations and network structure, while intrinsic plasticity is essential for the rebound of firing rates, suggesting that synaptic scaling and intrinsic plasticity can serve distinct functions in homeostatically regulating network dynamics.

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Posted October 02, 2019.
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Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics
Yue Wu, Keith B. Hengen, Gina G. Turrigiano, Julijana Gjorgjieva
bioRxiv 790410; doi: https://doi.org/10.1101/790410
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Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics
Yue Wu, Keith B. Hengen, Gina G. Turrigiano, Julijana Gjorgjieva
bioRxiv 790410; doi: https://doi.org/10.1101/790410

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