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Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology
View ORCID ProfileErik L. Bao, Satish K. Nandakumar, Xiaotian Liao, View ORCID ProfileAlexander Bick, Juha Karjalainen, View ORCID ProfileMarcin Tabaka, Olga I. Gan, Aki Havulinna, Tuomo Kiiskinen, View ORCID ProfileCaleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, View ORCID ProfilePradeep Natarajan, Claire Churchhouse, 23andMe Research Team, Björn Nilsson, Peter W.F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Million Veteran Program, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Christopher J. O’Donnell, View ORCID ProfileMark J. Daly, Michael Milyavsky, Sekar Kathiresan, View ORCID ProfileVijay G. Sankaran
doi: https://doi.org/10.1101/790626
Erik L. Bao
1Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA, USA
Satish K. Nandakumar
1Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
Xiaotian Liao
1Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
Alexander Bick
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
5VA Boston Healthcare, Section of Cardiology and Department of Medicine, Boston, MA, USA
Juha Karjalainen
6Institute for Molecular Medicine Finland, Helsinki, Finland
Marcin Tabaka
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
Olga I. Gan
7Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada
8Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Aki Havulinna
6Institute for Molecular Medicine Finland, Helsinki, Finland
Tuomo Kiiskinen
6Institute for Molecular Medicine Finland, Helsinki, Finland
Caleb A. Lareau
1Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA
Aitzkoa L. de Lapuente Portilla
10Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, SE-221 84 Lund University, Lund, Sweden
Bo Li
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
11Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Connor Emdin
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Veryan Codd
12Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Christopher P. Nelson
12Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Pradeep Natarajan
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
13Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114
Claire Churchhouse
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
1423andMe, Inc, Mountain View, CA, USA
Björn Nilsson
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
10Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, SE-221 84 Lund University, Lund, Sweden
Peter W.F. Wilson
15Atlanta VA Medical Center, Atlanta, GA, USA
16Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA
Kelly Cho
17Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA
18Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Saiju Pyarajan
17Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA
J. Michael Gaziano
17Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA
18Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Nilesh J. Samani
12Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester, United Kingdom
Aviv Regev
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
Aarno Palotie
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Institute for Molecular Medicine Finland, Helsinki, Finland
Benjamin M. Neale
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
John E. Dick
7Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada
8Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Christopher J. O’Donnell
5VA Boston Healthcare, Section of Cardiology and Department of Medicine, Boston, MA, USA
18Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Mark J. Daly
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Institute for Molecular Medicine Finland, Helsinki, Finland
Michael Milyavsky
19Department of Pathology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Sekar Kathiresan
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Vijay G. Sankaran
1Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
20Harvard Stem Cell Institute, Cambridge, MA, USA
Article usage
Posted October 08, 2019.
Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology
Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander Bick, Juha Karjalainen, Marcin Tabaka, Olga I. Gan, Aki Havulinna, Tuomo Kiiskinen, Caleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, Pradeep Natarajan, Claire Churchhouse, 23andMe Research Team, Björn Nilsson, Peter W.F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Million Veteran Program, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Christopher J. O’Donnell, Mark J. Daly, Michael Milyavsky, Sekar Kathiresan, Vijay G. Sankaran
bioRxiv 790626; doi: https://doi.org/10.1101/790626
Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology
Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander Bick, Juha Karjalainen, Marcin Tabaka, Olga I. Gan, Aki Havulinna, Tuomo Kiiskinen, Caleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, Pradeep Natarajan, Claire Churchhouse, 23andMe Research Team, Björn Nilsson, Peter W.F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Million Veteran Program, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Christopher J. O’Donnell, Mark J. Daly, Michael Milyavsky, Sekar Kathiresan, Vijay G. Sankaran
bioRxiv 790626; doi: https://doi.org/10.1101/790626
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