Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Spontaneous variability in gamma dynamics described by a linear harmonic oscillator driven by noise

Georgios Spyropoulos, Jarrod Robert Dowdall, Marieke Louise Schölvinck, Conrado Arturo Bosman, Bruss Lima, Alina Peter, Irene Onorato, Johanna Klon-Lipok, Rasmus Roese, Sergio Neuenschwander, Wolf Singer, Martin Vinck, Pascal Fries
doi: https://doi.org/10.1101/793729
Georgios Spyropoulos
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pascal.fries@esi-frankfurt.de martin.vinck@esi-frankfurt.de georgios.spyropoulos@esi-frankfurt.de
Jarrod Robert Dowdall
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
2International Max Planck Research School for Neural Circuits
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marieke Louise Schölvinck
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Conrado Arturo Bosman
3Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands
4Swammerdam Institute for Life Sciences, Center for Neuroscience, Faculty of Science, University of Amsterdam, 1098 XH Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruss Lima
5Max Planck Institute for Brain Research, 60438 Frankfurt, Germany
6Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alina Peter
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
2International Max Planck Research School for Neural Circuits
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irene Onorato
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
2International Max Planck Research School for Neural Circuits
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johanna Klon-Lipok
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
5Max Planck Institute for Brain Research, 60438 Frankfurt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rasmus Roese
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sergio Neuenschwander
5Max Planck Institute for Brain Research, 60438 Frankfurt, Germany
7Brain Institute, Federal University of Rio Grande do Norte, 59056-450 Natal, Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wolf Singer
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
5Max Planck Institute for Brain Research, 60438 Frankfurt, Germany
8Frankfurt Institute for Advanced Studies, 60438 Frankfurt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Vinck
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pascal.fries@esi-frankfurt.de martin.vinck@esi-frankfurt.de georgios.spyropoulos@esi-frankfurt.de
Pascal Fries
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany
3Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pascal.fries@esi-frankfurt.de martin.vinck@esi-frankfurt.de georgios.spyropoulos@esi-frankfurt.de
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

SUMMARY

Circuits of excitatory and inhibitory neurons can generate rhythmic activity in the gamma frequency-range (30-80Hz). Individual gamma-cycles show spontaneous variability in amplitude and duration. The mechanisms underlying this variability are not fully understood. We recorded local-field-potentials (LFPs) and spikes from awake macaque V1, and developed a noise-robust method to detect gamma-cycle amplitudes and durations. Amplitudes and durations showed a weak but positive correlation. This correlation, and the joint amplitude-duration distribution, is well reproduced by a dampened harmonic oscillator driven by stochastic noise. We show that this model accurately fits LFP power spectra and is equivalent to a linear PING (Pyramidal Interneuron Network Gamma) circuit. The model recapitulates two additional features of V1 gamma: (1) Amplitude-duration correlations decrease with oscillation strength; (2) Amplitudes and durations exhibit strong and weak autocorrelations, respectively, depending on oscillation strength. Finally, longer gamma-cycles are associated with stronger spike-synchrony, but lower spike-rates in both (putative) excitatory and inhibitory neurons. In sum, V1 gamma-dynamics are well described by the simplest possible model of gamma: A linear harmonic oscillator driven by noise.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted May 20, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Spontaneous variability in gamma dynamics described by a linear harmonic oscillator driven by noise
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Spontaneous variability in gamma dynamics described by a linear harmonic oscillator driven by noise
Georgios Spyropoulos, Jarrod Robert Dowdall, Marieke Louise Schölvinck, Conrado Arturo Bosman, Bruss Lima, Alina Peter, Irene Onorato, Johanna Klon-Lipok, Rasmus Roese, Sergio Neuenschwander, Wolf Singer, Martin Vinck, Pascal Fries
bioRxiv 793729; doi: https://doi.org/10.1101/793729
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Spontaneous variability in gamma dynamics described by a linear harmonic oscillator driven by noise
Georgios Spyropoulos, Jarrod Robert Dowdall, Marieke Louise Schölvinck, Conrado Arturo Bosman, Bruss Lima, Alina Peter, Irene Onorato, Johanna Klon-Lipok, Rasmus Roese, Sergio Neuenschwander, Wolf Singer, Martin Vinck, Pascal Fries
bioRxiv 793729; doi: https://doi.org/10.1101/793729

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4380)
  • Biochemistry (9571)
  • Bioengineering (7084)
  • Bioinformatics (24832)
  • Biophysics (12595)
  • Cancer Biology (9949)
  • Cell Biology (14344)
  • Clinical Trials (138)
  • Developmental Biology (7943)
  • Ecology (12095)
  • Epidemiology (2067)
  • Evolutionary Biology (15980)
  • Genetics (10915)
  • Genomics (14730)
  • Immunology (9862)
  • Microbiology (23636)
  • Molecular Biology (9472)
  • Neuroscience (50824)
  • Paleontology (369)
  • Pathology (1538)
  • Pharmacology and Toxicology (2678)
  • Physiology (4009)
  • Plant Biology (8653)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2389)
  • Systems Biology (6422)
  • Zoology (1345)