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Evolution of the DAN gene family in vertebrates

View ORCID ProfileJuan C. Opazo, View ORCID ProfileFederico G. Hoffmann, Kattina Zavala, View ORCID ProfileScott V. Edwards
doi: https://doi.org/10.1101/794404
Juan C. Opazo
1Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
2David Rockefeller Center for Latin American Studies, Harvard University, Cambridge, MA 02138, USA
3Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD)
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  • For correspondence: jopazo@gmail.com
Federico G. Hoffmann
4Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Mississippi State, 39762, USA
5Institute for Genomics, Biocomputing, and Biotechnology, Mississippi State University, Mississippi State, 39762, USA
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Kattina Zavala
1Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
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Scott V. Edwards
6Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
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Abstract

The DAN gene family (DAN, Differential screening-selected gene Aberrant in Neuroblastoma) is a group of genes that is expressed during development and plays fundamental roles in limb bud formation and digitation, kidney formation and morphogenesis and left-right axis specification. During adulthood the expression of these genes are associated with diseases, including cancer. Although most of the attention to this group of genes has been dedicated to understanding its role in physiology and development, its evolutionary history remains poorly understood. Thus, the goal of this study is to investigate the evolutionary history of the DAN gene family in vertebrates, with the objective of complementing the already abundant physiological information with an evolutionary context. Our results recovered the monophyly of all DAN gene family members and divide them into five main groups. In addition to the well-known DAN genes, our phylogenetic results revealed the presence of two new DAN gene lineages; one is only retained in cephalochordates, whereas the other one (GREM3) was only identified in cartilaginous fish, holostean fish, and coelacanth. According to the phyletic distribution of the genes, the ancestor of gnathostomes possessed a repertoire of eight DAN genes, and during the radiation of the group GREM1, GREM2, SOST, SOSTDC1, and NBL1 were retained in all major groups, whereas, GREM3, CER1, and DAND5 were differentially lost.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Cite as: Opazo JC, Hoffmann FG, Zavala K, Edwards SV (2020) Evolution of the DAN gene family in vertebrates. bioRxiv, 794404, ver. 3 peer-reviewed and recommended by PCI Evolutionary Biology. doi: 10.1101/794404

  • ver. 3 peer-reviewed and recommended by PCI Evolutionary Biology. doi: 10.1101/794404

  • https://zenodo.org/record/3911345#.XvmRKJMzY3E

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 29, 2020.
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Evolution of the DAN gene family in vertebrates
Juan C. Opazo, Federico G. Hoffmann, Kattina Zavala, Scott V. Edwards
bioRxiv 794404; doi: https://doi.org/10.1101/794404
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Evolution of the DAN gene family in vertebrates
Juan C. Opazo, Federico G. Hoffmann, Kattina Zavala, Scott V. Edwards
bioRxiv 794404; doi: https://doi.org/10.1101/794404

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