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Range expansion shifts clonal interference patterns in evolving populations

View ORCID ProfileNikhil Krishnan, View ORCID ProfileJacob G. Scott
doi: https://doi.org/10.1101/794867
Nikhil Krishnan
Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA
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Jacob G. Scott
Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USATranslational Hematology Oncology Research and Radiation Oncology, Cleveland Clinic, Cleveland OH, 44106, USADepartment of Physics, Case Western Reserve University, Cleveland, OH, 44106, USA
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  • For correspondence: npk13@case.edu scottj10@ccf.org
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ABSTRACT

The movement of a population through space can have profound impacts on its evolution, as observed theoretically, experimentally, and clinically. Furthermore, it has been observed that mutants emerging at the spreading front develop higher frequencies in the population than their counterparts further from the front. Here we use fundamental arguments from population genetics regarding expected time scales of beneficial mutant establishment and fixation in a population undergoing range expansion to characterize the degree of clonal interference expected in various regions while the population is migrating. By quantifying the degree of clonal interference along the wave front of a population undergoing range expansion using a measure we term the ‘Clonal Interference Index’, we show that evolution is increasingly mutation-limited toward the wave tip. In addition, we predict that the degree of clonal interference varies non-monotonically with respect to position along the wave front. The work presented here extends a powerful framework in population genetics to a canonical physical model of range expansion, which we hope allows for continued development of these models in both fields.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 07, 2019.
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Range expansion shifts clonal interference patterns in evolving populations
Nikhil Krishnan, Jacob G. Scott
bioRxiv 794867; doi: https://doi.org/10.1101/794867
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Range expansion shifts clonal interference patterns in evolving populations
Nikhil Krishnan, Jacob G. Scott
bioRxiv 794867; doi: https://doi.org/10.1101/794867

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