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History
- October 8, 2019.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Kazuyoshi Ishigaki1,2,3,4,
- Masato Akiyama1,5,
- Masahiro Kanai1,4,6,
- Atsushi Takahashi1,7,
- Eiryo Kawakami8,9,
- Hiroki Sugishita9,
- Saori Sakaue1,10,11,
- Nana Matoba1,12,
- Siew-Kee Low1,13,
- Yukinori Okada1,10,14,15,
- Chikashi Terao16,
- Tiffany Amariuta2,3,4,6,17,
- Steven Gazal4,18,
- Yuta Kochi19,
- Momoko Horikoshi20,
- Ken Suzuki1,10,20,21,
- Kaoru Ito22,
- Yukihide Momozawa23,
- Makoto Hirata24,
- Koichi Matsuda25,
- Masashi Ikeda26,
- Nakao Iwata26,
- Shiro Ikegawa27,
- Ikuyo Kou27,
- Toshihiro Tanaka22,28,
- Hidewaki Nakagawa29,
- Akari Suzuki19,
- Tomomitsu Hirota30,
- Mayumi Tamari30,
- Kazuaki Chayama31,
- Daiki Miki31,
- Masaki Mori32,
- Satoshi Nagayama33,
- Yataro Daigo34,35,
- Yoshio Miki36,
- Toyomasa Katagiri37,
- Osamu Ogawa38,
- Wataru Obara39,
- Hidemi Ito40,41,
- Teruhiko Yoshida42,
- Issei Imoto43,44,45,
- Takashi Takahashi46,
- Chizu Tanikawa47,
- Takao Suzuki48,
- Nobuaki Sinozaki48,
- Shiro Minami49,
- Hiroki Yamaguchi50,
- Satoshi Asai51,52,
- Yasuo Takahashi52,
- Ken Yamaji53,
- Kazuhisa Takahashi54,
- Tomoaki Fujioka39,
- Ryo Takata39,
- Hideki Yanai55,
- Akihide Masumoto56,
- Yukihiro Koretsune57,
- Hiromu Kutsumi58,
- Masahiko Higashiyama59,
- Shigeo Murayama60,
- Naoko Minegishi61,
- Kichiya Suzuki61,
- Kozo Tanno62,
- Atsushi Shimizu62,
- Taiki Yamaji63,
- Motoki Iwasaki63,
- Norie Sawada63,
- Hirokazu Uemura64,
- Keitaro Tanaka65,
- Mariko Naito66,67,
- Makoto Sasaki62,
- Kenji Wakai66,
- Shoichiro Tsugane68,
- Masayuki Yamamoto61,
- Kazuhiko Yamamoto19,
- Yoshinori Murakami69,
- Yusuke Nakamura70,
- Soumya Raychaudhuri*,2,3,4,6,17,71,
- Johji Inazawa*,72,73,
- Toshimasa Yamauchi*,21,
- Takashi Kadowaki*,21,
- Michiaki Kubo*,74 and
- Yoichiro Kamatani*,1,75
- 1Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
- 3Center for Data Sciences, Harvard Medical School, Boston, MA 02115, USA
- 4Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- 5Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University. Fukuoka, Japan
- 6Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
- 7Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan
- 8Healthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, Medical Sciences Innovation Hub Program (MIH), RIKEN, Yokohama, Japan
- 9Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 10Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
- 11Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
- 12Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC, USA
- 13Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan
- 14Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan
- 15Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan
- 16Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 17Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA
- 18Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- 19Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 20Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 21Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- 22Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 23Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 24Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- 25Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
- 26Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
- 27Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 28Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan
- 29Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan
- 30Laboratory for Respiratory and Allergic Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 31Department of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
- 32Department of Gastroenterological Surgery Graduate School of Medicine, Osaka University, Osaka, Japan
- 33Department of Gastroenterological Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
- 34Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Shiga, Japan
- 35Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- 36Department of Genetic Diagnosis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
- 37Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan
- 38Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
- 39Department of Urology, Iwate Medical University School of Medicine, Iwate, Japan
- 40Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan
- 41Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
- 42Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
- 43Division of Molecular Genetics, Aichi Cancer Center Research Institute, Nagoya, Japan
- 44Risk Assessment Center, Aichi Caner Center Hospital, Nagoya, Japan
- 45Division of Cancer Genetics, Graduate School of Medicine, Nagoya University, Nagoya, Japan
- 46Aichi Cancer Center, Nagoya, Japan
- 47Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
- 48Tokushukai Group, Tokyo, Japan
- 49Department of Bioregulation, Nippon Medical School, Tokyo, Japan
- 50Department of Hematology, Nippon Medical School, Tokyo, Japan
- 51Division of Pharmacology, Department of Biomedical Science, Nihon University School of Medicine, Tokyo, Japan
- 52Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan
- 53Department of Internal Medicine and Rheumatology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 54Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 55Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan
- 56Aso Iizuka Hospital, Fukuoka, Japan
- 57National Hospital Organization Osaka National Hospital, Osaka, Japan
- 58Center for Clinical Research and Advanced Medicine, Shiga University of Medical Science, Shiga, Japan
- 59Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan
- 60Department of Neurology and Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
- 61Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
- 62Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
- 63Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
- 64Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
- 65Department of Preventive Medicine, Saga University Faculty of Medicine, Saga, Japan
- 66Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
- 67Department of Oral Epidemiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
- 68Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
- 69Division of Molecular Pathology, The Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan
- 70Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan
- 71Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
- 72Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
- 73Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan
- 74RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 75Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
- ↵*Correspondence and requests for materials should be addressed to: Soumya Raychaudhuri, M.D., Ph.D., soumya{at}broadinstitute.org, Center for Data Sciences, Harvard Medical School, Boston, MA, USA. Yoichiro Kamatani, M.D., Ph.D., yoichiro.kamatani{at}riken.jp, Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.