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Multicentric tracking of multiple agents by anterior cingulate cortex during pursuit and evasion

Seng Bum Michael Yoo, Jiaxin Cindy Tu, View ORCID ProfileBenjamin Yost Hayden
doi: https://doi.org/10.1101/796375
Seng Bum Michael Yoo
Department of Neuroscience, Center for Magnetic Resonance Research, and Center for Neuroengineering, University of Minnesota, MN, 55455, United States of America
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  • For correspondence: sbyoo.ur.bcs@gmail.com
Jiaxin Cindy Tu
Department of Neuroscience, Center for Magnetic Resonance Research, and Center for Neuroengineering, University of Minnesota, MN, 55455, United States of America
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Benjamin Yost Hayden
Department of Neuroscience, Center for Magnetic Resonance Research, and Center for Neuroengineering, University of Minnesota, MN, 55455, United States of America
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  • ORCID record for Benjamin Yost Hayden
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SUMMARY

Successful pursuit and evasion require rapid and precise coordination of navigation with adaptive motor control. We hypothesized that the dorsal anterior cingulate cortex (dACC), which communicates bidirectionally with both the hippocampal complex and premotor/motor areas, would serve a mapping role in this process. We recorded responses of dACC ensembles in two macaques performing a joystick-controlled continuous pursuit/evasion task. We found that dACC multiplexes two sets of signals, (1) world-centric variables that together form a representation of the position and velocity of all relevant agents (self, prey, and predator) in the virtual world, and (2) avatar-centric variables, i.e. self-prey distance and angle. Both sets of variables are multiplexed within an overlapping set of neurons. Our results suggest that dACC may contribute to pursuit and evasion by computing and continuously updating a multicentric representation of the unfolding task state, and support the hypothesis that it plays a high-level abstract role in the control of behavior.

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Posted October 07, 2019.
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Multicentric tracking of multiple agents by anterior cingulate cortex during pursuit and evasion
Seng Bum Michael Yoo, Jiaxin Cindy Tu, Benjamin Yost Hayden
bioRxiv 796375; doi: https://doi.org/10.1101/796375
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Multicentric tracking of multiple agents by anterior cingulate cortex during pursuit and evasion
Seng Bum Michael Yoo, Jiaxin Cindy Tu, Benjamin Yost Hayden
bioRxiv 796375; doi: https://doi.org/10.1101/796375

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