Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

Rajagopal Murugan; Stephen W. Scally; Giulia Costa; Ghulam Mustafa; Elaine Thai; Tizian Decker; Alexandre Bosch; Katherine Prieto; Elena A. Levashina; Jean-Philippe Julien; Hedda Wardemann

doi:10.1101/798769

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Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

View ORCID ProfileRajagopal Murugan, View ORCID ProfileStephen W. Scally, Giulia Costa, Ghulam Mustafa, Elaine Thai, Tizian Decker, View ORCID ProfileAlexandre Bosch, Katherine Prieto, View ORCID ProfileElena A. Levashina, View ORCID ProfileJean-Philippe Julien, View ORCID ProfileHedda Wardemann

doi: https://doi.org/10.1101/798769

Rajagopal Murugan

1B Cell Immunology, German Cancer Research Institute (DKFZ), Heidelberg 69120, Germany

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Stephen W. Scally

2Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada

3Department of Biochemistry, University of Toronto, ON M5G 0A4, Canada

4Department of Immunology, University of Toronto, ON M5G 0A4, Canada

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Giulia Costa

5Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin 10117, Germany

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Ghulam Mustafa

1B Cell Immunology, German Cancer Research Institute (DKFZ), Heidelberg 69120, Germany

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Elaine Thai

2Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada

4Department of Immunology, University of Toronto, ON M5G 0A4, Canada

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Tizian Decker

1B Cell Immunology, German Cancer Research Institute (DKFZ), Heidelberg 69120, Germany

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Alexandre Bosch

2Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada

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Katherine Prieto

2Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada

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Elena A. Levashina

5Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin 10117, Germany

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For correspondence: h.wardemann@dkfz.de jean-philippe.julien@sickkids.ca levashina@mpiib-berlin.mpg.de

Jean-Philippe Julien

2Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada

3Department of Biochemistry, University of Toronto, ON M5G 0A4, Canada

4Department of Immunology, University of Toronto, ON M5G 0A4, Canada

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For correspondence: h.wardemann@dkfz.de jean-philippe.julien@sickkids.ca levashina@mpiib-berlin.mpg.de

Hedda Wardemann

1B Cell Immunology, German Cancer Research Institute (DKFZ), Heidelberg 69120, Germany

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For correspondence: h.wardemann@dkfz.de jean-philippe.julien@sickkids.ca levashina@mpiib-berlin.mpg.de

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Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

Rajagopal Murugan, Stephen W. Scally, Giulia Costa, Ghulam Mustafa, Elaine Thai, Tizian Decker, Alexandre Bosch, Katherine Prieto, Elena A. Levashina, Jean-Philippe Julien, Hedda Wardemann

bioRxiv 798769; doi: https://doi.org/10.1101/798769

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Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

Rajagopal Murugan, Stephen W. Scally, Giulia Costa, Ghulam Mustafa, Elaine Thai, Tizian Decker, Alexandre Bosch, Katherine Prieto, Elena A. Levashina, Jean-Philippe Julien, Hedda Wardemann

bioRxiv 798769; doi: https://doi.org/10.1101/798769

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