New Results
A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation
View ORCID ProfileErik C.B. Johnson, Eric B. Dammer, Duc M. Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan C. Troncoso, Madhav Thambisetty, Thomas J. Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, Eric M. Reiman, Vahram Haroutunian, Minghui Wang, Eric Schadt, Bin Zhang, View ORCID ProfileDennis W. Dickson, Nilufer Ertekin-Taner, Todd E. Golde, Vladislav A. Petyuk, Philip L. De Jager, David A. Bennett, View ORCID ProfileThomas S. Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M. Shulman, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
doi: https://doi.org/10.1101/802959
Erik C.B. Johnson
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Eric B. Dammer
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Duc M. Duong
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Lingyan Ping
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Maotian Zhou
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Luming Yin
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Lenora A. Higginbotham
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Andrew Guajardo
4Johns Hopkins School of Medicine, Baltimore, MD, USA
Bartholomew White
4Johns Hopkins School of Medicine, Baltimore, MD, USA
Juan C. Troncoso
4Johns Hopkins School of Medicine, Baltimore, MD, USA
Madhav Thambisetty
5Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Thomas J. Montine
6Department of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA
Edward B. Lee
7Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
John Q. Trojanowski
7Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Thomas G. Beach
8Banner Sun Health Research Institute, Sun City, AZ, USA
Eric M. Reiman
9Banner Alzheimer’s Institute, Arizona State University and University of Arizona, Phoenix, AZ, USA
Vahram Haroutunian
10Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA
11JJ Peters VA Medical Center MIRECC, 130 West Kingsbridge Road, Bronx, NY, USA
Minghui Wang
12Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA
Eric Schadt
12Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA
Bin Zhang
12Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA
Dennis W. Dickson
13Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
Nilufer Ertekin-Taner
13Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
14Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
Todd E. Golde
15Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Vladislav A. Petyuk
16Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
Philip L. De Jager
17Center for Translational & Computational Neuroimmunology, Department of Neurology, Taub Institute, Columbia University Irving Medical Center, New York Presbyterian Hospital, New York, NY, USA
David A. Bennett
18Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Thomas S. Wingo
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Srikant Rangaraju
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Ihab Hajjar
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Joshua M. Shulman
19Departments of Neurology, Neuroscience, and Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA
20Jan and Dan Duncan Neurologic Research Institute, Texas Children’s Hospital, Houston, TX, USA
James J. Lah
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Allan I. Levey
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Nicholas T. Seyfried
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Posted January 23, 2020.
A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation
Erik C.B. Johnson, Eric B. Dammer, Duc M. Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan C. Troncoso, Madhav Thambisetty, Thomas J. Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, Eric M. Reiman, Vahram Haroutunian, Minghui Wang, Eric Schadt, Bin Zhang, Dennis W. Dickson, Nilufer Ertekin-Taner, Todd E. Golde, Vladislav A. Petyuk, Philip L. De Jager, David A. Bennett, Thomas S. Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M. Shulman, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
bioRxiv 802959; doi: https://doi.org/10.1101/802959
A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation
Erik C.B. Johnson, Eric B. Dammer, Duc M. Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan C. Troncoso, Madhav Thambisetty, Thomas J. Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, Eric M. Reiman, Vahram Haroutunian, Minghui Wang, Eric Schadt, Bin Zhang, Dennis W. Dickson, Nilufer Ertekin-Taner, Todd E. Golde, Vladislav A. Petyuk, Philip L. De Jager, David A. Bennett, Thomas S. Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M. Shulman, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
bioRxiv 802959; doi: https://doi.org/10.1101/802959
Subject Area
Subject Areas
- Biochemistry (11715)
- Bioengineering (8723)
- Bioinformatics (29129)
- Biophysics (14936)
- Cancer Biology (12049)
- Cell Biology (17359)
- Clinical Trials (138)
- Developmental Biology (9406)
- Ecology (14144)
- Epidemiology (2067)
- Evolutionary Biology (18268)
- Genetics (12221)
- Genomics (16767)
- Immunology (11843)
- Microbiology (28014)
- Molecular Biology (11560)
- Neuroscience (60814)
- Paleontology (450)
- Pathology (1864)
- Pharmacology and Toxicology (3231)
- Physiology (4940)
- Plant Biology (10384)
- Synthetic Biology (2878)
- Systems Biology (7333)
- Zoology (1642)