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Population-specific causal disease effect sizes in functionally important regions impacted by selection
View ORCID ProfileHuwenbo Shi, View ORCID ProfileSteven Gazal, View ORCID ProfileMasahiro Kanai, View ORCID ProfileEvan M. Koch, View ORCID ProfileArmin P. Schoech, Samuel S. Kim, View ORCID ProfileYang Luo, View ORCID ProfileTiffany Amariuta, Yukinori Okada, View ORCID ProfileSoumya Raychaudhuri, View ORCID ProfileShamil R. Sunyaev, View ORCID ProfileAlkes L. Price
doi: https://doi.org/10.1101/803452
Huwenbo Shi
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Steven Gazal
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Masahiro Kanai
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
6Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
Evan M. Koch
7Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
8Department of Medicine, Harvard Medical School, Boston, MA, USA
Armin P. Schoech
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Samuel S. Kim
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
10Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
Yang Luo
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
7Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
11Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
12Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Tiffany Amariuta
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
11Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
12Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
13Graduate School of Arts andSciences, Harvard University, Cambridge, MA, USA
Yukinori Okada
6Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
14Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
Soumya Raychaudhuri
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
5Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
7Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
11Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
12Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
15Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
Shamil R. Sunyaev
7Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
8Department of Medicine, Harvard Medical School, Boston, MA, USA
Alkes L. Price
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Posted October 30, 2019.
Population-specific causal disease effect sizes in functionally important regions impacted by selection
Huwenbo Shi, Steven Gazal, Masahiro Kanai, Evan M. Koch, Armin P. Schoech, Samuel S. Kim, Yang Luo, Tiffany Amariuta, Yukinori Okada, Soumya Raychaudhuri, Shamil R. Sunyaev, Alkes L. Price
bioRxiv 803452; doi: https://doi.org/10.1101/803452
Population-specific causal disease effect sizes in functionally important regions impacted by selection
Huwenbo Shi, Steven Gazal, Masahiro Kanai, Evan M. Koch, Armin P. Schoech, Samuel S. Kim, Yang Luo, Tiffany Amariuta, Yukinori Okada, Soumya Raychaudhuri, Shamil R. Sunyaev, Alkes L. Price
bioRxiv 803452; doi: https://doi.org/10.1101/803452
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