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Estimating relative CWD susceptibility and disease progression in farmed whitetail deer with rare PRNP alleles

View ORCID ProfileNJ Haley, K Merrett, A Buros Stein, D Simpson, A Carlton, G Mitchell, A Staskevicius, T Nichols, AD Lehmkuhl, BV Thomsen
doi: https://doi.org/10.1101/804773
NJ Haley
1Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ
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  • For correspondence: nicholas.j.haley@gmail.com
K Merrett
1Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ
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A Buros Stein
2Office of Research and Sponsored Programs, Midwestern University, Glendale, AZ
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D Simpson
3Simpson Whitetails Genetic Testing, Belleville, MI
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A Carlton
3Simpson Whitetails Genetic Testing, Belleville, MI
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G Mitchell
4National and OIE Reference Laboratory for Scrapie and CWD, Canadian Food Inspection Agency, Ottawa Laboratory-Fallowfield, Ottawa, Ontario, Canada
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A Staskevicius
4National and OIE Reference Laboratory for Scrapie and CWD, Canadian Food Inspection Agency, Ottawa Laboratory-Fallowfield, Ottawa, Ontario, Canada
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T Nichols
5United States Department of Agriculture, APHIS, Veterinary Services, Cervid Health Program, Fort Collins, CO, USA
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AD Lehmkuhl
6United States Department of Agriculture, APHIS, Veterinary Services, National Veterinary Services Laboratories, Ames, IA, USA
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BV Thomsen
6United States Department of Agriculture, APHIS, Veterinary Services, National Veterinary Services Laboratories, Ames, IA, USA
7United States Department of Agriculture, APHIS, Veterinary Services, Center for Veterinary Biologics, Ames, IA, USA
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Abstract

Chronic wasting disease is a prion disease affecting both free-ranging and farmed cervids in North America and Scandinavia. A range of cervid species have been found to be susceptible, each with variations in the gene for the normal prion protein, PRNP, reportedly influencing both disease susceptibility and progression in the respective hosts. Despite the finding of several different PRNP alleles in whitetail deer, the majority of past research has focused on two of the more common alleles identified – the 96G and 96S alleles. In the present study, we evaluate both infection status and disease stage in nearly 2100 farmed deer depopulated in the United States and Canada, including 714 CWD-positive deer and correlate our findings with PRNP genotype, including the more rare 95H, 116G, and 226K alleles. We found significant differences in either likelihood of being found infected or disease stage (and in many cases both) at the time of depopulation in all genotypes present, relative to the most common 96GG genotype. Despite high prevalence in many of the herds examined, infection was not found in several of the reported genotypes. These findings suggest that additional research is necessary to more properly define the role that these genotypes may play in managing CWD in both farmed and free-ranging whitetail deer, with consideration for factors including relative fitness levels, incubation periods, and the kinetics of shedding in animals with these rare genotypes.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted October 14, 2019.
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Estimating relative CWD susceptibility and disease progression in farmed whitetail deer with rare PRNP alleles
NJ Haley, K Merrett, A Buros Stein, D Simpson, A Carlton, G Mitchell, A Staskevicius, T Nichols, AD Lehmkuhl, BV Thomsen
bioRxiv 804773; doi: https://doi.org/10.1101/804773
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Estimating relative CWD susceptibility and disease progression in farmed whitetail deer with rare PRNP alleles
NJ Haley, K Merrett, A Buros Stein, D Simpson, A Carlton, G Mitchell, A Staskevicius, T Nichols, AD Lehmkuhl, BV Thomsen
bioRxiv 804773; doi: https://doi.org/10.1101/804773

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