Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
Confirmatory Results

Time distributed data analysis by Cosinor.Online application

View ORCID ProfileLubos Molcan
doi: https://doi.org/10.1101/805960
Lubos Molcan
Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lubos Molcan
  • For correspondence: lubos.molcan@uniba.sk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Data/Code
  • Preview PDF
Loading

Abstract

Disturbed biological oscillations often represent pathology and thus have a prognostic character. The most studied are 24-h (circadian) and shorter (ultradian) oscillations from them. A cosinor analysis often evaluates the presence and significance of circadian and ultradian rhythms. Skilled researchers can use MATLAB, R, Python, or other programming languages, while those less experienced often use outdated applications that require a specific operating system version or outdated add-ons. Therefore, we developed CosinorOnline, a simple web-based application coded in PHP and JavaScript to evaluate the presence and significance of different oscillations. Users can set the period length on the application’s page and insert their data. The results consist of a numerical evaluation and an adjustable plot. There is also a unique identifier to reload or immediately delete data analysis within one month. After this period, all data are automatically deleted from the app. We compared the functionality of CosinorOnline with Cosinor2 (R package) and Chronos-Fit (Windows app). The 24-h variability analysis was identical for all three applications. The evaluation of ultradian variability was the same for CosinorOnline and Cosinor2 and slightly different for Chronos-Fit. CosinorOnline and Chronos-Fit result in acrophase in units of time (decimal form), while Cosinor2 is in radians. In conclusion, CosinorOnline is a simple, easy-to-use web application to inspect time data that provides reliable results without additional installation and runs in modern web browsers. The application does not track users and aims to help users quickly decide whether their data is suitable for more profound analysis using cosinor analysis.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The application has done more than 50,000 calculations these days, and the bioRxiv paper has 31 citations in quality journals. Therefore, I significantly revised the paper because users deserve it. 1) I shortened the "software usage" in Material and methods and expanded the "Comparison with other applications" section about ultradian variability. 2) Due to multiple comparisons, I expanded the results from one table to two figures, three tables and two supplementary tables. 3) I edited the discussion, focused more on comparing the application with other softwares, and extended the limitations of the application.

  • https://cosinor.online

  • https://docs.google.com/spreadsheets/d/1YPmNgiAq5j06JfnVDMC5MOazgJZkAr3O/edit?usp=sharing&ouid=114929052193528458001&rtpof=true&sd=true

  • https://docs.google.com/spreadsheets/d/1ToQ4qYXR8EJgCXgrxJxehjt3hRd7i1oX/edit?usp=sharing&ouid=114929052193528458001&rtpof=true&sd=true

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted January 18, 2023.
Download PDF

Supplementary Material

Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Time distributed data analysis by Cosinor.Online application
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Time distributed data analysis by Cosinor.Online application
Lubos Molcan
bioRxiv 805960; doi: https://doi.org/10.1101/805960
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Time distributed data analysis by Cosinor.Online application
Lubos Molcan
bioRxiv 805960; doi: https://doi.org/10.1101/805960

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioinformatics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4224)
  • Biochemistry (9101)
  • Bioengineering (6749)
  • Bioinformatics (23935)
  • Biophysics (12086)
  • Cancer Biology (9491)
  • Cell Biology (13738)
  • Clinical Trials (138)
  • Developmental Biology (7614)
  • Ecology (11656)
  • Epidemiology (2066)
  • Evolutionary Biology (15476)
  • Genetics (10615)
  • Genomics (14292)
  • Immunology (9456)
  • Microbiology (22773)
  • Molecular Biology (9069)
  • Neuroscience (48840)
  • Paleontology (354)
  • Pathology (1479)
  • Pharmacology and Toxicology (2562)
  • Physiology (3822)
  • Plant Biology (8307)
  • Scientific Communication and Education (1467)
  • Synthetic Biology (2289)
  • Systems Biology (6170)
  • Zoology (1297)