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Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring required for female reproductive behaviors in Drosophila

Irmgard U. Haussmann, View ORCID ProfileMohanakarthik P. Nallasivan, View ORCID ProfileDaniela Scocchia, View ORCID ProfileAlberto Civetta, View ORCID ProfileMatthias Soller
doi: https://doi.org/10.1101/806380
Irmgard U. Haussmann
1School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
2Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, B5 3TN, United Kingdom
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Mohanakarthik P. Nallasivan
1School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
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Daniela Scocchia
1School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
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Alberto Civetta
3Department of Biology, University of Winnipeg, Winnipeg, Canada
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Matthias Soller
1School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
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  • For correspondence: m.soller@bham.ac.uk
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Abstract

The post-mating response induced by male-derived sex-peptide in Drosophila females is a well-established model to elucidate how complex innate behaviors are hard-wired into the brain. Here, we found that the channel nuclear pore protein Nup54 is essential for the sex-peptide response as viable mutant alleles do not lay eggs and reduce receptivity upon sex-peptide exposure. Nup54 directs correct wiring of few adult brain neurons that express pickpocket and are required for egg laying, but channel Nups also mediate sexual differentiation and male X-chromosome dosage compensation. Consistent with links of Nups to speciation, the Nup54 promoter is a hot spot for rapid evolution and Nup54 is differentially expressed in the brain. These results implicate altered expression of Nup54 to the onset of speciation processes leading to changes in neuronal wiring and sexual differentiation as a response to sexual conflict arising from male-derived SP to direct the female post-mating response.

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Posted October 15, 2019.
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Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring required for female reproductive behaviors in Drosophila
Irmgard U. Haussmann, Mohanakarthik P. Nallasivan, Daniela Scocchia, Alberto Civetta, Matthias Soller
bioRxiv 806380; doi: https://doi.org/10.1101/806380
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Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring required for female reproductive behaviors in Drosophila
Irmgard U. Haussmann, Mohanakarthik P. Nallasivan, Daniela Scocchia, Alberto Civetta, Matthias Soller
bioRxiv 806380; doi: https://doi.org/10.1101/806380

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