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Neural signatures of loss of consciousness and its recovery by thalamic stimulation

Jacob A. Donoghue, André M. Bastos, Jorge Yanar, Simon Kornblith, Meredith Mahnke, Emery N. Brown, Earl K. Miller
doi: https://doi.org/10.1101/806687
Jacob A. Donoghue
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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André M. Bastos
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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Jorge Yanar
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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Simon Kornblith
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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Meredith Mahnke
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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Emery N. Brown
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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Earl K. Miller
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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  • For correspondence: ekmiller@mit.edu
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Abstract

We know that general anesthesia produces unconsciousness but not quite how. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non-human primates (NHPs) with propofol. Unconsciousness was marked by slow frequency (∼1 Hz) oscillations in local field potentials, entraining local spiking to Up states alternating with Down states of little spiking, and decreased higher frequency (>4 Hz) coherence. The thalamus contributed to cortical rhythms. Its stimulation “awakened” anesthetized NHPs and reversed the electrophysiologic features of unconsciousness. Unconsciousness thus resulted from slow frequency hypersynchrony and loss of high-frequency dynamics, partly mediated by the thalamus, that disrupts cortical communication/integration.

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Posted October 17, 2019.
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Neural signatures of loss of consciousness and its recovery by thalamic stimulation
Jacob A. Donoghue, André M. Bastos, Jorge Yanar, Simon Kornblith, Meredith Mahnke, Emery N. Brown, Earl K. Miller
bioRxiv 806687; doi: https://doi.org/10.1101/806687
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Neural signatures of loss of consciousness and its recovery by thalamic stimulation
Jacob A. Donoghue, André M. Bastos, Jorge Yanar, Simon Kornblith, Meredith Mahnke, Emery N. Brown, Earl K. Miller
bioRxiv 806687; doi: https://doi.org/10.1101/806687

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