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CRISPR/Cas9 targeting of an oncogenic KRAS mutant allele induces efficient tumor regression
View ORCID ProfileQianqian Gao, Wenjie Ouyang, Bin Kang, Xu Han, Ying Xiong, Renpeng Ding, Yijian Li, Fei Wang, Lei Huang, Lei Chen, Dan Wang, Xuan Dong, Zhao Zhang, Yanshan Li, Baichen Ze, Yong Hou, Huanming Yang, Yuanyuan Ma, Ying Gu, Cheng-chi Chao
doi: https://doi.org/10.1101/807578
Qianqian Gao
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Wenjie Ouyang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Bin Kang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Xu Han
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Ying Xiong
4Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China
Renpeng Ding
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
5BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, 518083, China
Yijian Li
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Fei Wang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
5BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, 518083, China
Lei Huang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
5BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, 518083, China
Lei Chen
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Dan Wang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Xuan Dong
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Zhao Zhang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Yanshan Li
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Baichen Ze
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Yong Hou
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Huanming Yang
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
6James D. Watson Institute of Genome Sciences, Hangzhou 310058, China
Yuanyuan Ma
4Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China
Ying Gu
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
Cheng-chi Chao
1Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518083, China
2China National GeneBank, BGI-Shenzhen, Jinsha Road, Shenzhen 518120, China
3Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518083, China
7Ab Vision, Inc, Milpitas, California, USA.
Article usage
Posted October 17, 2019.
CRISPR/Cas9 targeting of an oncogenic KRAS mutant allele induces efficient tumor regression
Qianqian Gao, Wenjie Ouyang, Bin Kang, Xu Han, Ying Xiong, Renpeng Ding, Yijian Li, Fei Wang, Lei Huang, Lei Chen, Dan Wang, Xuan Dong, Zhao Zhang, Yanshan Li, Baichen Ze, Yong Hou, Huanming Yang, Yuanyuan Ma, Ying Gu, Cheng-chi Chao
bioRxiv 807578; doi: https://doi.org/10.1101/807578
CRISPR/Cas9 targeting of an oncogenic KRAS mutant allele induces efficient tumor regression
Qianqian Gao, Wenjie Ouyang, Bin Kang, Xu Han, Ying Xiong, Renpeng Ding, Yijian Li, Fei Wang, Lei Huang, Lei Chen, Dan Wang, Xuan Dong, Zhao Zhang, Yanshan Li, Baichen Ze, Yong Hou, Huanming Yang, Yuanyuan Ma, Ying Gu, Cheng-chi Chao
bioRxiv 807578; doi: https://doi.org/10.1101/807578
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