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Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses
View ORCID ProfileHayley A. McNamara, Azza H. Idris, View ORCID ProfileHenry J. Sutton, Barbara J. Flynn, Yeping Cai, Kevin Wiehe, Kirsten E. Lyke, Deepyan Chatterjee, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Mattia Bonsignori, Robert A. Seder, View ORCID ProfileIan A. Cockburn
doi: https://doi.org/10.1101/808543
Hayley A. McNamara
1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
Azza H. Idris
2Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Henry J. Sutton
1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
Barbara J. Flynn
2Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Yeping Cai
1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
Kevin Wiehe
3Duke Human Vaccine Institute, Durham, NC 27710, USA
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Kirsten E. Lyke
5Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Deepyan Chatterjee
1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
Natasha KC
6Sanaria Inc., Rockville, MD 20850, USA
Sumana Chakravarty
6Sanaria Inc., Rockville, MD 20850, USA
B. Kim Lee Sim
6Sanaria Inc., Rockville, MD 20850, USA
Stephen L. Hoffman
5Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mattia Bonsignori
3Duke Human Vaccine Institute, Durham, NC 27710, USA
4Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Robert A. Seder
2Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Ian A. Cockburn
1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601, Australia
Posted October 18, 2019.
Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses
Hayley A. McNamara, Azza H. Idris, Henry J. Sutton, Barbara J. Flynn, Yeping Cai, Kevin Wiehe, Kirsten E. Lyke, Deepyan Chatterjee, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Mattia Bonsignori, Robert A. Seder, Ian A. Cockburn
bioRxiv 808543; doi: https://doi.org/10.1101/808543
Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses
Hayley A. McNamara, Azza H. Idris, Henry J. Sutton, Barbara J. Flynn, Yeping Cai, Kevin Wiehe, Kirsten E. Lyke, Deepyan Chatterjee, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Mattia Bonsignori, Robert A. Seder, Ian A. Cockburn
bioRxiv 808543; doi: https://doi.org/10.1101/808543
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