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Prefrontal cortex exhibits multi-dimensional dynamic encoding during decision-making

View ORCID ProfileMikio C. Aoi, Valerio Mante, Jonathan W. Pillow
doi: https://doi.org/10.1101/808584
Mikio C. Aoi
1Department of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544
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  • For correspondence: maoi@princeton.edu
Valerio Mante
2Institute of Neuroinformatics, University of Zurich, Zurich, Switzerland
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Jonathan W. Pillow
1Department of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544
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Abstract

Recent work has suggested that prefrontal cortex (PFC) plays a key role in context-dependent perceptual decision-making. Here we investigate population-level coding of decision variables in monkey PFC using a new method for identifying task-relevant dimensions of neural activity. Our analyses reveal that, in contrast to one-dimensional attractor models, PFC has a multi-dimensional code for decisions, context, and relevant as well as irrelevant sensory information. Moreover, these representations evolve in time, with an early linear accumulation phase followed by a phase with rotational dynamics. We identify the dimensions of neural activity associated with these phases, and show that they are not the product of distinct populations, but of a single population with broad tuning characteristics. Finally, we use model-based decoding to show that the transition from linear to rotational dynamics coincides with a sustained plateau in decoding accuracy, revealing that rotational dynamics in PFC preserve sensory as well as choice information for the duration of the stimulus integration period.

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  • http://www.mikioaoi.com

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 21, 2019.
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Prefrontal cortex exhibits multi-dimensional dynamic encoding during decision-making
Mikio C. Aoi, Valerio Mante, Jonathan W. Pillow
bioRxiv 808584; doi: https://doi.org/10.1101/808584
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Prefrontal cortex exhibits multi-dimensional dynamic encoding during decision-making
Mikio C. Aoi, Valerio Mante, Jonathan W. Pillow
bioRxiv 808584; doi: https://doi.org/10.1101/808584

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