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Flexible recruitment of memory-based choice representations by human medial-frontal cortex

Juri Minxha, Ralph Adolphs, Stefano Fusi, Adam N. Mamelak, Ueli Rutishauser
doi: https://doi.org/10.1101/809673
Juri Minxha
1Computation and Neural Systems Program, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA
3Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA
4Center for Theoretical Neuroscience, College of Physicians and Surgeons, Columbia University
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  • For correspondence: jminxha@gmail.com
Ralph Adolphs
1Computation and Neural Systems Program, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA
2Division of Humanities and Social Sciences, California Institute of Technology, Pasadena CA
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Stefano Fusi
6Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA
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Adam N. Mamelak
3Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA
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Ueli Rutishauser
1Computation and Neural Systems Program, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena CA
3Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA
5Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA
6Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA
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Summary

Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions. This process depends on medial frontal cortex (MFC) and the medial temporal lobe (MTL), but it remains unknown how these structures interact during memory retrieval. We recorded single neurons in MFC and MTL while human subjects switched between making memory and categorization-based decisions. Here we show that MFC rapidly implements changing task demands by utilizing different subspaces of neural activity during different types of decisions. Choices requiring memory retrieval selectively engaged phase-locking between theta-frequency band oscillations in MTL and MFC neurons. Choice neurons signaled decisions independent of output modality. In contrast, no effect of task demands was seen locally in the MTL. This work reveals a mechanism for selectively engaging memory retrieval and shows that unlike perceptual decision-making, memory-related information is only represented in frontal cortex when choices require it.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 18, 2019.
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Flexible recruitment of memory-based choice representations by human medial-frontal cortex
Juri Minxha, Ralph Adolphs, Stefano Fusi, Adam N. Mamelak, Ueli Rutishauser
bioRxiv 809673; doi: https://doi.org/10.1101/809673
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Flexible recruitment of memory-based choice representations by human medial-frontal cortex
Juri Minxha, Ralph Adolphs, Stefano Fusi, Adam N. Mamelak, Ueli Rutishauser
bioRxiv 809673; doi: https://doi.org/10.1101/809673

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