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Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics

Ludwig A. Hothorn, Felix M. Kluxen, Mario Hasler
doi: https://doi.org/10.1101/810408
Ludwig A. Hothorn
Leibniz University Hannover, ADAMA Deutschland GmbH, Christian-Albrechts-University of Kiel, Germany
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  • For correspondence: ludwig@hothorn.de
Felix M. Kluxen
Leibniz University Hannover, ADAMA Deutschland GmbH, Christian-Albrechts-University of Kiel, Germany
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Mario Hasler
Leibniz University Hannover, ADAMA Deutschland GmbH, Christian-Albrechts-University of Kiel, Germany
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Abstract

Sometimes a re-analysis of toxicological data is useful. However, this usually requires the availability of the original data and in many cases only summary data are available in the publications. Here the generation of pseudo-data under certain assumptions using extension packages in the open-source project R on statistical computing is shown. Several case studies are used to illustrate the applicability in regulatory toxicology.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 18, 2019.
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Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics
Ludwig A. Hothorn, Felix M. Kluxen, Mario Hasler
bioRxiv 810408; doi: https://doi.org/10.1101/810408
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Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics
Ludwig A. Hothorn, Felix M. Kluxen, Mario Hasler
bioRxiv 810408; doi: https://doi.org/10.1101/810408

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