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Spontaneous Traveling Cortical Waves Gate Perception in Awake Behaving Primates

View ORCID ProfileZachary W. Davis, View ORCID ProfileLyle Muller, View ORCID ProfileJulio-Martinez Trujillo, View ORCID ProfileTerrence Sejnowski, View ORCID ProfileJohn H. Reynolds
doi: https://doi.org/10.1101/811471
Zachary W. Davis
1The Salk Institute for Biological Studies, La Jolla, CA, USA
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  • For correspondence: zdavis@salk.edu reynolds@salk.edu
Lyle Muller
1The Salk Institute for Biological Studies, La Jolla, CA, USA
2Department of Applied Mathematics, Western University, London, ON, Canada
3Brain and Mind Institute, Western University, London, ON, Canada
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Julio-Martinez Trujillo
3Brain and Mind Institute, Western University, London, ON, Canada
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Terrence Sejnowski
1The Salk Institute for Biological Studies, La Jolla, CA, USA
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John H. Reynolds
1The Salk Institute for Biological Studies, La Jolla, CA, USA
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Abstract

Perceptual sensitivity varies from moment to moment. One potential source of variability is spontaneous fluctuations in cortical activity that can travel as a wave. Spontaneous traveling waves have been reported during anesthesia, but questioned as to whether they are relevant to waking cortical function. Using newly developed analytic techniques, we find spontaneous waves of activity in extrastriate visual cortex of awake marmosets (Callithrix jacchus). In monkeys trained to detect faint visual targets, the timing and position of spontaneous traveling waves, prior to target onset, predict the magnitude of evoked activity and the likelihood of detection. In contrast, spatially disorganized fluctuations of neural activity are much less predictive. These results reveal an important role for spontaneous traveling waves in sensory processing through modulating neural and perceptual sensitivity.

One Sentence Summary Fluctuations in cortical activity often travel as waves, shape incoming sensory information, and affect conscious perception.

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Posted October 21, 2019.
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Spontaneous Traveling Cortical Waves Gate Perception in Awake Behaving Primates
Zachary W. Davis, Lyle Muller, Julio-Martinez Trujillo, Terrence Sejnowski, John H. Reynolds
bioRxiv 811471; doi: https://doi.org/10.1101/811471
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Spontaneous Traveling Cortical Waves Gate Perception in Awake Behaving Primates
Zachary W. Davis, Lyle Muller, Julio-Martinez Trujillo, Terrence Sejnowski, John H. Reynolds
bioRxiv 811471; doi: https://doi.org/10.1101/811471

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