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Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline

Jonathan Volpatti, Yukari Endo, Linda Groom, Stephanie Brennan, Ramil Noche, View ORCID ProfileWilliam Zuercher, Peter Roy, Robert T. Dirksen, James J. Dowling
doi: https://doi.org/10.1101/813097
Jonathan Volpatti
1Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, CA
2Department of Molecular Genetics, University of Toronto, Toronto, CA
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Yukari Endo
1Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, CA
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Linda Groom
3Department of Pharmacology, University of Rochester, Rochester, NY, USA
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Stephanie Brennan
1Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, CA
2Department of Molecular Genetics, University of Toronto, Toronto, CA
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Ramil Noche
1Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, CA
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William Zuercher
4UNC Eshelman School of Pharmacy, SGC Center for Chemical Biology, University of North Carolina at Chapel Hill, NC, USA
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  • ORCID record for William Zuercher
Peter Roy
2Department of Molecular Genetics, University of Toronto, Toronto, CA
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Robert T. Dirksen
3Department of Pharmacology, University of Rochester, Rochester, NY, USA
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James J. Dowling
1Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, CA
2Department of Molecular Genetics, University of Toronto, Toronto, CA
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  • For correspondence: james.dowling@sickkids.ca
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Article Information

doi 
https://doi.org/10.1101/813097
History 
  • October 21, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Jonathan Volpatti1,2,
  2. Yukari Endo1,
  3. Linda Groom3,
  4. Stephanie Brennan1,2,
  5. Ramil Noche1,
  6. William Zuercher4,
  7. Peter Roy2,
  8. Robert T. Dirksen3 and
  9. James J. Dowling1,2,*
  1. 1Program for Genetics and Genome Biology, Hospital for Sick Children, Toronto, CA
  2. 2Department of Molecular Genetics, University of Toronto, Toronto, CA
  3. 3Department of Pharmacology, University of Rochester, Rochester, NY, USA
  4. 4UNC Eshelman School of Pharmacy, SGC Center for Chemical Biology, University of North Carolina at Chapel Hill, NC, USA
  1. ↵*To Whom Correspondence Should be Addressed: James J. Dowling, MD, PhD, Program of Genetics and Genome Biology and Division of Neurology, Hospital for Sick Children, 686 Bay Street, Toronto, ON CAN M5G0A4, james.dowling{at}sickkids.ca
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Posted October 21, 2019.
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Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline
Jonathan Volpatti, Yukari Endo, Linda Groom, Stephanie Brennan, Ramil Noche, William Zuercher, Peter Roy, Robert T. Dirksen, James J. Dowling
bioRxiv 813097; doi: https://doi.org/10.1101/813097
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Identification of drug modifiers for RYR1 related myopathy using a multi-species discovery pipeline
Jonathan Volpatti, Yukari Endo, Linda Groom, Stephanie Brennan, Ramil Noche, William Zuercher, Peter Roy, Robert T. Dirksen, James J. Dowling
bioRxiv 813097; doi: https://doi.org/10.1101/813097

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