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Hippocampal hub neurons maintain unique functional properties throughout their lifetime

View ORCID ProfileMarco Bocchio, Claire Gouny, David Angulo-Garcia, Tom Toulat, Thomas Tressard, Agnès Baude, Rosa Cossart
doi: https://doi.org/10.1101/813923
Marco Bocchio
INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems, Parc Scientifique de Luminy, 13273, Marseille, France
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  • ORCID record for Marco Bocchio
Claire Gouny
INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems, Parc Scientifique de Luminy, 13273, Marseille, France
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David Angulo-Garcia
INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems, Parc Scientifique de Luminy, 13273, Marseille, FranceGrupo de Modelado Computacional–Dinámica y Complejidad de Sistemas, Instituto de Matemáticas Aplicadas, Universidad de Cartagena, 130001, Cartagena, Colombia
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Tom Toulat
INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems, Parc Scientifique de Luminy, 13273, Marseille, France
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Thomas Tressard
INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems, Parc Scientifique de Luminy, 13273, Marseille, France
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Agnès Baude
INMED (INSERM U1249), Aix-Marseille University, Turing Center for Living Systems, Parc Scientifique de Luminy, 13273, Marseille, France
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Rosa Cossart
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  • For correspondence: rosa.cossart@inserm.fr
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Abstract

The temporal embryonic origins of cortical GABA neurons are critical for their specialization. In the neonatal hippocampus, GABA cells born the earliest (ebGABAs) operate as ‘hubs’ by orchestrating neuronal dynamics. However, their fate remains largely unknown. To fill this gap, we have examined CA1 ebGABAs using a combination of electrophysiology, neurochemical analysis, optogenetic connectivity mapping as well as ex vivo and in vivo calcium imaging. We show that CA1 ebGABAs not only operate as hubs during development, but also maintain distinct morpho-physiological and connectivity profiles, including a bias for long-range targets and local excitatory inputs. In vivo, ebGABAs signal a variety of network states, including the activation of local CA1 assemblies. Hence, ebGABAs are specified from birth to ensure unique functions throughout their lifetime. In the adult brain, this may take the form of a long-range hub role through the coordination of cell assemblies across distant regions.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 22, 2019.
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Hippocampal hub neurons maintain unique functional properties throughout their lifetime
Marco Bocchio, Claire Gouny, David Angulo-Garcia, Tom Toulat, Thomas Tressard, Agnès Baude, Rosa Cossart
bioRxiv 813923; doi: https://doi.org/10.1101/813923
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Hippocampal hub neurons maintain unique functional properties throughout their lifetime
Marco Bocchio, Claire Gouny, David Angulo-Garcia, Tom Toulat, Thomas Tressard, Agnès Baude, Rosa Cossart
bioRxiv 813923; doi: https://doi.org/10.1101/813923

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