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Widespread dose-dependent effects of RNA expression and splicing on complex diseases and traits
View ORCID ProfileAlvaro N Barbeira, Rodrigo Bonazzola, View ORCID ProfileEric R Gamazon, View ORCID ProfileYanyu Liang, View ORCID ProfileYoSon Park, View ORCID ProfileSarah Kim-Hellmuth, View ORCID ProfileGao Wang, Zhuoxun Jiang, Dan Zhou, View ORCID ProfileFarhad Hormozdiari, Boxiang Liu, Abhiram Rao, View ORCID ProfileAndrew R Hamel, View ORCID ProfileMilton D Pividori, View ORCID ProfileFrançois Aguet, GTEx GWAS Working Group, View ORCID ProfileLisa Bastarache, View ORCID ProfileDaniel M Jordan, Marie Verbanck, View ORCID ProfileRon Do, GTEx Consortium, View ORCID ProfileMatthew Stephens, Kristin Ardlie, Mark McCarthy, View ORCID ProfileStephen B Montgomery, View ORCID ProfileAyellet V Segrè, View ORCID ProfileChristopher D. Brown, View ORCID ProfileTuuli Lappalainen, View ORCID ProfileXiaoquan Wen, View ORCID ProfileHae Kyung Im
doi: https://doi.org/10.1101/814350
Alvaro N Barbeira
1Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA
Rodrigo Bonazzola
1Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA
Eric R Gamazon
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
3Data Science Institute, Vanderbilt University, Nashville, TN, USA
4Clare Hall, University of Cambridge, Cambridge, UK
5MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Yanyu Liang
1Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA
YoSon Park
6Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
Sarah Kim-Hellmuth
8Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany
9New York Genome Center, New York, NY, USA
10Department of Systems Biology, Columbia University, New York, NY, USA
Gao Wang
11Department of Human Genetics, University of Chicago, Chicago, IL, USA
Zhuoxun Jiang
1Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA
Dan Zhou
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Farhad Hormozdiari
12The Broad Institute of MIT and Harvard, Cambridge, MA, USA
13Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Boxiang Liu
14Department of Biology, Stanford University, Stanford, California 94305, USA
Abhiram Rao
14Department of Biology, Stanford University, Stanford, California 94305, USA
Andrew R Hamel
12The Broad Institute of MIT and Harvard, Cambridge, MA, USA
15Ocular Genomics Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
Milton D Pividori
1Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA
François Aguet
12The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Lisa Bastarache
16Department of Biomedical Informatics, Department of Medicine, Vanderbilt University, Nashville, TN, USA
17Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Daniel M Jordan
18Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
19Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
20The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount sinai, New York, New York, USA
Marie Verbanck
18Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
19Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
20The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount sinai, New York, New York, USA
21Université de Paris - EA 7537 BIOSTM, France
Ron Do
18Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
19Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
20The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount sinai, New York, New York, USA
Matthew Stephens
11Department of Human Genetics, University of Chicago, Chicago, IL, USA
Kristin Ardlie
12The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Mark McCarthy
22University of Oxford, United Kingdom
Stephen B Montgomery
23Department of Genetics, Stanford University, Stanford, CA, USA
24Department of Pathology, Stanford University, Stanford, CA, USA
Ayellet V Segrè
12The Broad Institute of MIT and Harvard, Cambridge, MA, USA
15Ocular Genomics Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
Christopher D. Brown
6Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
Tuuli Lappalainen
9New York Genome Center, New York, NY, USA
10Department of Systems Biology, Columbia University, New York, NY, USA
Xiaoquan Wen
25Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
Hae Kyung Im
1Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA
Posted October 22, 2019.
Widespread dose-dependent effects of RNA expression and splicing on complex diseases and traits
Alvaro N Barbeira, Rodrigo Bonazzola, Eric R Gamazon, Yanyu Liang, YoSon Park, Sarah Kim-Hellmuth, Gao Wang, Zhuoxun Jiang, Dan Zhou, Farhad Hormozdiari, Boxiang Liu, Abhiram Rao, Andrew R Hamel, Milton D Pividori, François Aguet, GTEx GWAS Working Group, Lisa Bastarache, Daniel M Jordan, Marie Verbanck, Ron Do, GTEx Consortium, Matthew Stephens, Kristin Ardlie, Mark McCarthy, Stephen B Montgomery, Ayellet V Segrè, Christopher D. Brown, Tuuli Lappalainen, Xiaoquan Wen, Hae Kyung Im
bioRxiv 814350; doi: https://doi.org/10.1101/814350
Widespread dose-dependent effects of RNA expression and splicing on complex diseases and traits
Alvaro N Barbeira, Rodrigo Bonazzola, Eric R Gamazon, Yanyu Liang, YoSon Park, Sarah Kim-Hellmuth, Gao Wang, Zhuoxun Jiang, Dan Zhou, Farhad Hormozdiari, Boxiang Liu, Abhiram Rao, Andrew R Hamel, Milton D Pividori, François Aguet, GTEx GWAS Working Group, Lisa Bastarache, Daniel M Jordan, Marie Verbanck, Ron Do, GTEx Consortium, Matthew Stephens, Kristin Ardlie, Mark McCarthy, Stephen B Montgomery, Ayellet V Segrè, Christopher D. Brown, Tuuli Lappalainen, Xiaoquan Wen, Hae Kyung Im
bioRxiv 814350; doi: https://doi.org/10.1101/814350
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