Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders

Snow Bach, Niamh M. Ryan, Paolo Guasoni, Aiden Corvin, Daniela Tropea
doi: https://doi.org/10.1101/819573
Snow Bach
1School of Mathematical Sciences, Dublin City University, Glasnevin, Dublin 9, D09 W6Y4, Ireland
2Neuropsychiatric Genetics, Department of Psychiatry, Trinity College Dublin, School of Medicine, Trinity Translational Medicine Institute, St James Hospital, Dublin, Ireland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Niamh M. Ryan
2Neuropsychiatric Genetics, Department of Psychiatry, Trinity College Dublin, School of Medicine, Trinity Translational Medicine Institute, St James Hospital, Dublin, Ireland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paolo Guasoni
1School of Mathematical Sciences, Dublin City University, Glasnevin, Dublin 9, D09 W6Y4, Ireland
3Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, MA 02215, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aiden Corvin
2Neuropsychiatric Genetics, Department of Psychiatry, Trinity College Dublin, School of Medicine, Trinity Translational Medicine Institute, St James Hospital, Dublin, Ireland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniela Tropea
2Neuropsychiatric Genetics, Department of Psychiatry, Trinity College Dublin, School of Medicine, Trinity Translational Medicine Institute, St James Hospital, Dublin, Ireland
4Trinity College Institute of Neuroscience, Trinity College Dublin, Lloyd Building, Dublin 2, Dublin, Ireland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tropead@tcd.ie
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Methyl-CpG binding protein 2 (MeCP2) is a chromatin-binding protein and a modulator of gene expression. Initially identified as an oncogene, MECP2 is now mostly associated to Rett Syndrome, a neurodevelopmental condition, though there is evidence of its influence in other brain disorders.

We design a procedure that considers several binding properties of MeCP2 and we screen for potential targets across neurological and neuropsychiatric conditions.

We find MeCP2 target genes associated to a range of disorders, including - among others-Alzheimer Disease, Autism, Attention Deficit Hyperactivity Disorder and Multiple Sclerosis. The analysis of biological mechanisms and pathways modulated by MeCP2’s target genes shows that such mechanisms are involved in three main processes: neuronal transmission, immuno-reactivity and development.

These results suggest that similar symptoms present in different pathologies have a common molecular basis, and that treatments for one condition have potential applications to related disorders.

  • Abbreviations

    AD
    Alzheimer’s Disease
    ADHD
    Attention Deficit Hyperactivity Disorder
    ALS
    Amyotrophic Lateral Sclerosis
    ASD
    Autism Spectrum Disorder
    AUC
    Area Under the Curve
    BDNF
    Brain-Derived Neurotrophic Factor
    CDLK4
    Cyclin-Dependant Kinase-Like 4
    CNV
    Copy Number Variant
    DA
    Dopamine
    GWAS
    Genome-Wide Association Study
    HTT
    Huntington’s Disease
    MDD
    Major Depressive Disorder
    MeCP2
    Methyl-CpG Binding Protein 2
    MEF2C
    Myocyte Enhancer Factor 2C
    miRNA
    Micro RNA
    MS
    Multiple Sclerosis
    NDD
    Neurodevelopmental
    OCD
    Obsessive Compulsive Disorder
    PD
    Parkinson’s Disease
    PPI
    Protein-Protein Interaction
    PFM
    Position Frequency Matrix
    PWM
    Position Weight Matrix
    RTT
    Rett Syndrome
    ROC
    Receiver Operated Characteristics
    SCZ
    Schizophrenia
    TF
    Transcription Factor
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
    Back to top
    PreviousNext
    Posted October 28, 2019.
    Download PDF
    Email

    Thank you for your interest in spreading the word about bioRxiv.

    NOTE: Your email address is requested solely to identify you as the sender of this article.

    Enter multiple addresses on separate lines or separate them with commas.
    Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders
    (Your Name) has forwarded a page to you from bioRxiv
    (Your Name) thought you would like to see this page from the bioRxiv website.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Share
    Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders
    Snow Bach, Niamh M. Ryan, Paolo Guasoni, Aiden Corvin, Daniela Tropea
    bioRxiv 819573; doi: https://doi.org/10.1101/819573
    Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
    Citation Tools
    Methyl-CpG2-binding protein 2 mediates overlapping mechanisms across brain disorders
    Snow Bach, Niamh M. Ryan, Paolo Guasoni, Aiden Corvin, Daniela Tropea
    bioRxiv 819573; doi: https://doi.org/10.1101/819573

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Subject Area

    • Neuroscience
    Subject Areas
    All Articles
    • Animal Behavior and Cognition (4119)
    • Biochemistry (8828)
    • Bioengineering (6532)
    • Bioinformatics (23484)
    • Biophysics (11804)
    • Cancer Biology (9223)
    • Cell Biology (13336)
    • Clinical Trials (138)
    • Developmental Biology (7442)
    • Ecology (11425)
    • Epidemiology (2066)
    • Evolutionary Biology (15173)
    • Genetics (10452)
    • Genomics (14056)
    • Immunology (9187)
    • Microbiology (22198)
    • Molecular Biology (8823)
    • Neuroscience (47625)
    • Paleontology (351)
    • Pathology (1431)
    • Pharmacology and Toxicology (2493)
    • Physiology (3736)
    • Plant Biology (8090)
    • Scientific Communication and Education (1438)
    • Synthetic Biology (2224)
    • Systems Biology (6042)
    • Zoology (1254)