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Physical activity and risk of Alzheimer’s disease: a two-sample Mendelian randomization study

Sebastian E Baumeister, André Karch, Martin Bahls, View ORCID ProfileAlexander Teumer, Michael F Leitzmann, Hansjörg Baurecht
doi: https://doi.org/10.1101/819821
Sebastian E Baumeister
1Chair of Epidemiology, LMU München, UNIKA-T Augsburg, Augsburg, Germany
2Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany
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  • For correspondence: s.baumeister@unika-t.de
André Karch
3Institute of Epidemiology and Social Medicine, University of Münster, Germany
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Martin Bahls
4Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
5DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany
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Alexander Teumer
5DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany
6Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Michael F Leitzmann
7Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany
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Hansjörg Baurecht
7Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany
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ABSTRACT

Introduction Evidence from observational studies for the effect of physical activity on the risk of Alzheimer’s disease (AD) is inconclusive. We performed Mendelian randomization analysis to examine whether physical activity is a protective factor for AD.

Methods Summary data of genome-wide association studies on physical activity and AD were identified using PubMed and the GWAS catalog. The study population included 21,982 AD cases and 41,944 cognitively normal controls. Eight single nucleotide polymorphisms (SNP) known at P < 5×10−8 to be associated with accelerometer-assessed physical activity served as instrumental variables.

Results Genetically predicted accelerometer-assessed physical activity had no effect on the risk of AD (inverse variance weighted odds ratio [OR] per standard deviation (SD) increment: 1.03, 95% confidence interval: 0.97-1.10, P=0.332).

Discussion The present study does not support a relationship between physical activity and risk of AD, and suggests that previous observational studies might have been biased.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 29, 2019.
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Physical activity and risk of Alzheimer’s disease: a two-sample Mendelian randomization study
Sebastian E Baumeister, André Karch, Martin Bahls, Alexander Teumer, Michael F Leitzmann, Hansjörg Baurecht
bioRxiv 819821; doi: https://doi.org/10.1101/819821
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Physical activity and risk of Alzheimer’s disease: a two-sample Mendelian randomization study
Sebastian E Baumeister, André Karch, Martin Bahls, Alexander Teumer, Michael F Leitzmann, Hansjörg Baurecht
bioRxiv 819821; doi: https://doi.org/10.1101/819821

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