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Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets and alter host behaviour

View ORCID ProfileSílvia F. Henriques, View ORCID ProfileLúcia Serra, View ORCID ProfileAna Patrícia Francisco, View ORCID ProfileZita Carvalho-Santos, View ORCID ProfileCélia Baltazar, View ORCID ProfileAna Paula Elias, View ORCID ProfileMargarida Anjos, Tong Zhang, View ORCID ProfileOliver D. K. Maddocks, View ORCID ProfileCarlos Ribeiro
doi: https://doi.org/10.1101/821892
Sílvia F. Henriques
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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  • ORCID record for Sílvia F. Henriques
Lúcia Serra
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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  • ORCID record for Lúcia Serra
Ana Patrícia Francisco
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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Zita Carvalho-Santos
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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Célia Baltazar
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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  • ORCID record for Célia Baltazar
Ana Paula Elias
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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  • ORCID record for Ana Paula Elias
Margarida Anjos
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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  • ORCID record for Margarida Anjos
Tong Zhang
University of Glasgow Institute of Cancer Sciences, Switchback Road, Glasgow G61 1QH, UK
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Oliver D. K. Maddocks
University of Glasgow Institute of Cancer Sciences, Switchback Road, Glasgow G61 1QH, UK
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  • ORCID record for Oliver D. K. Maddocks
Carlos Ribeiro
Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, 1400-038, Portugal
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  • ORCID record for Carlos Ribeiro
  • For correspondence: carlos.ribeiro@neuro.fchampalimaud.org
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Abstract

The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in Drosophila melanogaster, Aceto-bacter pomorum (Ap) and Lactobacillus plantarum (Lp) establish a syntrophic relationship to overcome detrimental host diets and identify Ap as the bacterium altering the host’s feeding decisions. Specifically, we show that Lp generates lactate which is used by Ap to produce and provide amino acids that are essential to Lp allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for Ap to alter the fly’s protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets and to ensure the constant flow of metabolites used by effector bacteria to alter host behaviour.

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Posted October 29, 2019.
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Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets and alter host behaviour
Sílvia F. Henriques, Lúcia Serra, Ana Patrícia Francisco, Zita Carvalho-Santos, Célia Baltazar, Ana Paula Elias, Margarida Anjos, Tong Zhang, Oliver D. K. Maddocks, Carlos Ribeiro
bioRxiv 821892; doi: https://doi.org/10.1101/821892
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Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets and alter host behaviour
Sílvia F. Henriques, Lúcia Serra, Ana Patrícia Francisco, Zita Carvalho-Santos, Célia Baltazar, Ana Paula Elias, Margarida Anjos, Tong Zhang, Oliver D. K. Maddocks, Carlos Ribeiro
bioRxiv 821892; doi: https://doi.org/10.1101/821892

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