New Results
Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression
View ORCID ProfileTeresa Gagliano, Kalpit Shah, Sofia Gargani, Liyan Lao, Mansour Alsaleem, Jianing Chen, Vasileios Ntafis, Penghan Huang, Angeliki Ditsiou, Viviana Vella, Kritika Yadav, Kamila Bienkowska, Giulia Bresciani, Kai Kang, Leping Li, Philip Carter, Graeme Benstead-Hum, Timothy O’Hanlon, Michael Dean, Frances M.G. Pearl, Soo-Chin Lee, Emad A Rakha, Andrew R Green, Dimitris L. Kontoyiannis, Erwei Song, Justin Stebbing, View ORCID ProfileGeorgios Giamas
doi: https://doi.org/10.1101/822049
Teresa Gagliano
1Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Kalpit Shah
2Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA
3Bristol-Myers Squibb Co., Princeton, New Jersey 08543, USA
Sofia Gargani
4Division of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
Liyan Lao
5Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
Mansour Alsaleem
6Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, Nottingham City Hospital, University of Nottingham, Hucknall Road, Nottingham, NG5 1PB, UK
Jianing Chen
5Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
Vasileios Ntafis
4Division of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
Penghan Huang
5Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
Angeliki Ditsiou
1Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Viviana Vella
1Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Kritika Yadav
7Cancer Science Institute, Singapore, National University of Singapore
Kamila Bienkowska
1Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Giulia Bresciani
8Department of Medical Sciences, University of Ferrara, Italy
Kai Kang
9Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC, 27709, USA
Leping Li
9Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC, 27709, USA
Philip Carter
10Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 ONN, UK
Graeme Benstead-Hum
11Bioinformatics Group, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK
Timothy O’Hanlon
12Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA
Michael Dean
2Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA
Frances M.G. Pearl
11Bioinformatics Group, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK
Soo-Chin Lee
7Cancer Science Institute, Singapore, National University of Singapore
13Department of Haematology-Oncology, National University Cancer Institute, Singapore
14National University Health System, Singapore
Emad A Rakha
6Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, Nottingham City Hospital, University of Nottingham, Hucknall Road, Nottingham, NG5 1PB, UK
Andrew R Green
6Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, Nottingham City Hospital, University of Nottingham, Hucknall Road, Nottingham, NG5 1PB, UK
Dimitris L. Kontoyiannis
4Division of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
15Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Erwei Song
5Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
Justin Stebbing
10Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 ONN, UK
Georgios Giamas
1Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Article usage
Posted November 02, 2019.
Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression
Teresa Gagliano, Kalpit Shah, Sofia Gargani, Liyan Lao, Mansour Alsaleem, Jianing Chen, Vasileios Ntafis, Penghan Huang, Angeliki Ditsiou, Viviana Vella, Kritika Yadav, Kamila Bienkowska, Giulia Bresciani, Kai Kang, Leping Li, Philip Carter, Graeme Benstead-Hum, Timothy O’Hanlon, Michael Dean, Frances M.G. Pearl, Soo-Chin Lee, Emad A Rakha, Andrew R Green, Dimitris L. Kontoyiannis, Erwei Song, Justin Stebbing, Georgios Giamas
bioRxiv 822049; doi: https://doi.org/10.1101/822049
Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression
Teresa Gagliano, Kalpit Shah, Sofia Gargani, Liyan Lao, Mansour Alsaleem, Jianing Chen, Vasileios Ntafis, Penghan Huang, Angeliki Ditsiou, Viviana Vella, Kritika Yadav, Kamila Bienkowska, Giulia Bresciani, Kai Kang, Leping Li, Philip Carter, Graeme Benstead-Hum, Timothy O’Hanlon, Michael Dean, Frances M.G. Pearl, Soo-Chin Lee, Emad A Rakha, Andrew R Green, Dimitris L. Kontoyiannis, Erwei Song, Justin Stebbing, Georgios Giamas
bioRxiv 822049; doi: https://doi.org/10.1101/822049
Subject Area
Subject Areas
- Biochemistry (11739)
- Bioengineering (8750)
- Bioinformatics (29189)
- Biophysics (14967)
- Cancer Biology (12093)
- Cell Biology (17409)
- Clinical Trials (138)
- Developmental Biology (9419)
- Ecology (14178)
- Epidemiology (2067)
- Evolutionary Biology (18301)
- Genetics (12238)
- Genomics (16797)
- Immunology (11865)
- Microbiology (28068)
- Molecular Biology (11583)
- Neuroscience (60953)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4957)
- Plant Biology (10425)
- Synthetic Biology (2884)
- Systems Biology (7338)
- Zoology (1651)