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Rod-cone signal interference in the retina shapes perception in primates

Adree Songco-Aguas, William N Grimes, Fred Rieke
doi: https://doi.org/10.1101/825851
Adree Songco-Aguas
Department of Physiology and Biophysics, University of Washington, Seattle, WA
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William N Grimes
Department of Physiology and Biophysics, University of Washington, Seattle, WANational Institute of Neurological Disease and Stroke, NIH, Bethesda, MD
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Fred Rieke
Department of Physiology and Biophysics, University of Washington, Seattle, WA
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  • For correspondence: rieke@uw.edu
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Abstract

Linking the activity of neurons, circuits and synapses to human behavior is a fundamental goal of neuroscience. Meeting this goal is challenging, in part because behavior, particularly perception, often masks the complexity of the underlying neural circuits, and in part because of the significant behavioral differences between primates and animals like mice and flies in which genetic manipulations are relatively common. Here we relate circuit-level processing of rod and cone signals in the non-human primate retina to a known break in the normal seamlessness of human vision – a surprising inability to see high contrast flickering lights under specific conditions. We use electrophysiological recordings and perceptual experiments to identify key mechanisms that shape the retinal integration of rod- and cone-generated retinal signals. We incorporate these mechanistic insights into a predictive model that accurately captures the cancellation of rod- and cone-mediated responses and can explain the perceptual insensitivity to flicker.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted October 31, 2019.
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Rod-cone signal interference in the retina shapes perception in primates
Adree Songco-Aguas, William N Grimes, Fred Rieke
bioRxiv 825851; doi: https://doi.org/10.1101/825851
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Rod-cone signal interference in the retina shapes perception in primates
Adree Songco-Aguas, William N Grimes, Fred Rieke
bioRxiv 825851; doi: https://doi.org/10.1101/825851

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